The role of oxidative stress in non-alcoholic steatohepatitis

G.H. Koek, P. R. Liedorp, A. Bast

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-alcoholic fatty liver disease (NAFLD) has an increasing prevalence in Western society. Unfortunately, the pathogenesis of NAFLD, from hepatic lipid overload, steatosis to non-alcoholic steatohepatitis (NASH), is incompletely understood. Oxidative stress (OS) caused by reactive oxygen species is, however, known to be of major importance in the progression of this disease. Mitochondrial, microsomal, peroxisomal and endoplasmatic reticulum OS plays an important role in NASH. Overload of free fatty acids results in electron leakage during mitochrondrial beta-oxidation. Generation of lipid peroxides result in subsequent damage to hepatic membranes, proteins and DNA. Total anti-oxidant capacity, both enzymatic and non-enzymatic, is, unfortunately, insufficient to mitigate liver injury. Loss of this tightly controlled balance sets in motion an inflammatory cascade involving cytokines. Hepatic stellate cells are activated and synthesize connective tissue (fibrosis). Activation of caspases and hepatocyte cell death is mediated by the expression of death receptor Fas-ligand and Kupffer cell stimulation. This cascade could eventually lead to liver cirrhosis and carcinogenesis. Understanding the mechanisms of OS in the pathogenesis of NASH is important in the successful development of targeted therapeutic modalities.
Original languageEnglish
Pages (from-to)1297-1305
Number of pages9
JournalClinica Chimica Acta
Volume412
Issue number15-16
DOIs
Publication statusPublished - 15 Jul 2011

Keywords

  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis
  • Oxidative stress
  • Anti-oxidants
  • Lipid peroxidation
  • FATTY LIVER-DISEASE
  • GLYCATION END-PRODUCTS
  • ANTIOXIDANT ENZYME-ACTIVITIES
  • HEPATIC CYTOCHROME-P450 2E1
  • ACTIVATED RECEPTOR-ALPHA
  • SERUM THIOREDOXIN LEVELS
  • NECROSIS-FACTOR-ALPHA
  • DE-NOVO LIPOGENESIS
  • INSULIN-RESISTANCE
  • LIPID-PEROXIDATION

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