The Role of Obesity in Early and Long-Term Outcomes after Surgical Excision of Lung Oligometastases from Colorectal Cancer

Francesco Londero, Orlando Parise, William Grossi, Angelo Morelli, Gianluca Masullo, Michele Bartoletti, Cecilia Tetta, Ugolino Livi, Jos G. Maessen, Sandro Gelsomino*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Obesity correlates with better outcomes in many neoplastic conditions. The aim of this study was to assess its role in the prognosis and morbidity of patients submitted to resection of lung oligometastases from colorectal cancer. Seventy-six patients undergoing a first pulmonary metastasectomy were retrospectively included in the study. Seventeen (22.3%) were obese (body mass index (BMI) >30 kg/m(2)). Assessed outcomes were overall survival, time to recurrence, and incidence of post-operative complications. Median follow-up was 33 months (IQR 16-53). At follow-up, 37 patients (48.6%) died, whereas 39 (51.4%) were alive. A significant difference was found in the 3-year overall survival (obese 80% vs. non-obese 56.8%, p = 0.035). Competing risk analysis shows that the cumulative incidence of recurrence was not different between the two groups. Multivariate analysis reveals that the number of metastases (p = 0.028), post-operative pneumonia (p = 0.042), and DFS (p = 0.007) were significant predictors of death. Competing risk regression shows that no independent risk factor for recurrence has been identified. The complication rate was not different between the two groups (17.6% vs. 13.6%, p = 0.70). Obesity is a positive prognostic factor for survival after pulmonary metastasectomy for colorectal cancer. Overweight patients do not experience more post-operative complications. Our results need to be confirmed by large multicenter studies.

Original languageEnglish
Article number3566
Number of pages10
JournalJournal of Clinical Medicine
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 2020

Keywords

  • obesity
  • lung
  • oligometastases
  • surgery
  • colorectal cancer
  • BODY-MASS INDEX
  • POSTOPERATIVE COMPLICATIONS
  • PULMONARY METASTASES
  • SURVIVAL
  • PARADOX
  • ASSOCIATION
  • RESECTION
  • IMPACT
  • SURGERY
  • OVERWEIGHT

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