The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models

K.A. Demin; A.M. Lakstygal; P.A. Alekseeva; M. Sysoev; M.S. de Abreu; E.T. Alpyshov; N. Serikuly; D.M. Wang; M.Y. Wang; Z.C. Tang; D.N. Yan; T.V. Strekalova; A.D. Volgin; T.G. Arnstislayskaya; J.J. Wang; C. Song; A.V. Kalueff

doi:10.1016/j.aquatox.2019.02.015

The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models

K.A. Demin, A.M. Lakstygal, P.A. Alekseeva, M. Sysoev, M.S. de Abreu, E.T. Alpyshov, N. Serikuly, D.M. Wang, M.Y. Wang, Z.C. Tang, D.N. Yan, T.V. Strekalova, A.D. Volgin, T.G. Arnstislayskaya, J.J. Wang, C. Song, A.V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.

Original language	English
Pages (from-to)	44-55
Number of pages	12
Journal	Aquatic Toxicology
Volume	210
DOIs	https://doi.org/10.1016/j.aquatox.2019.02.015
Publication status	Published - 1 May 2019

Keywords

adult zebrafish
animal-models
aquatic models
gene-environment interactions
gut microbiota
individual-differences
individuality
intraspecies variation
juvenile rainbow-trout
neurobehavioral variation
risk-taking
sex-differences
wild-type zebrafish
zebrafish
zebrafish danio-rerio
ZEBRAFISH DANIO-RERIO
GENE-ENVIRONMENT INTERACTIONS
ANIMAL-MODELS
Intraspecies variation
WILD-TYPE ZEBRAFISH
JUVENILE RAINBOW-TROUT
RISK-TAKING
Aquatic models
Neurobehavioral variation
Zebrafish
GUT MICROBIOTA
ADULT ZEBRAFISH
INDIVIDUAL-DIFFERENCES
Individuality
SEX-DIFFERENCES

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10.1016/j.aquatox.2019.02.015

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Demin, K. A., Lakstygal, A. M., Alekseeva, P. A., Sysoev, M., de Abreu, M. S., Alpyshov, E. T., Serikuly, N., Wang, D. M., Wang, M. Y., Tang, Z. C., Yan, D. N., Strekalova, T. V., Volgin, A. D., Arnstislayskaya, T. G., Wang, J. J., Song, C., & Kalueff, A. V. (2019). The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models. Aquatic Toxicology, 210, 44-55. https://doi.org/10.1016/j.aquatox.2019.02.015

@article{cfd910d659d34e2890b4c9002535a49f,

title = "The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models",

abstract = "Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.",

keywords = "adult zebrafish, animal-models, aquatic models, gene-environment interactions, gut microbiota, individual-differences, individuality, intraspecies variation, juvenile rainbow-trout, neurobehavioral variation, risk-taking, sex-differences, wild-type zebrafish, zebrafish, zebrafish danio-rerio, ZEBRAFISH DANIO-RERIO, GENE-ENVIRONMENT INTERACTIONS, ANIMAL-MODELS, Intraspecies variation, WILD-TYPE ZEBRAFISH, JUVENILE RAINBOW-TROUT, RISK-TAKING, Aquatic models, Neurobehavioral variation, Zebrafish, GUT MICROBIOTA, ADULT ZEBRAFISH, INDIVIDUAL-DIFFERENCES, Individuality, SEX-DIFFERENCES",

author = "K.A. Demin and A.M. Lakstygal and P.A. Alekseeva and M. Sysoev and \{de Abreu\}, M.S. and E.T. Alpyshov and N. Serikuly and D.M. Wang and M.Y. Wang and Z.C. Tang and D.N. Yan and T.V. Strekalova and A.D. Volgin and T.G. Arnstislayskaya and J.J. Wang and C. Song and A.V. Kalueff",

note = "Funding Information: The research was supported by the Russian Foundation for Basic Research (RFBR) grant 16‐04‐00851 to AVK. KAD research is supported by the RFBR grant 18‐34‐00996 and Rector{\textquoteright}s Special Productivity Fellowship for SPSU PhD Students. AVK is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) coordinating this multi-laboratory collaborative project. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = may,

day = "1",

doi = "10.1016/j.aquatox.2019.02.015",

language = "English",

volume = "210",

pages = "44--55",

journal = "Aquatic Toxicology",

issn = "0166-445X",

publisher = "Elsevier B.V.",

}

Demin, KA, Lakstygal, AM, Alekseeva, PA, Sysoev, M, de Abreu, MS, Alpyshov, ET, Serikuly, N, Wang, DM, Wang, MY, Tang, ZC, Yan, DN, Strekalova, TV, Volgin, AD, Arnstislayskaya, TG, Wang, JJ, Song, C & Kalueff, AV 2019, 'The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models', Aquatic Toxicology, vol. 210, pp. 44-55. https://doi.org/10.1016/j.aquatox.2019.02.015

TY - JOUR

T1 - The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models

AU - Demin, K.A.

AU - Lakstygal, A.M.

AU - Alekseeva, P.A.

AU - Sysoev, M.

AU - de Abreu, M.S.

AU - Alpyshov, E.T.

AU - Serikuly, N.

AU - Wang, D.M.

AU - Wang, M.Y.

AU - Tang, Z.C.

AU - Yan, D.N.

AU - Strekalova, T.V.

AU - Volgin, A.D.

AU - Arnstislayskaya, T.G.

AU - Wang, J.J.

AU - Song, C.

AU - Kalueff, A.V.

N1 - Funding Information: The research was supported by the Russian Foundation for Basic Research (RFBR) grant 16‐04‐00851 to AVK. KAD research is supported by the RFBR grant 18‐34‐00996 and Rector’s Special Productivity Fellowship for SPSU PhD Students. AVK is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) coordinating this multi-laboratory collaborative project. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.

AB - Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.

KW - adult zebrafish

KW - animal-models

KW - aquatic models

KW - gene-environment interactions

KW - gut microbiota

KW - individual-differences

KW - individuality

KW - intraspecies variation

KW - juvenile rainbow-trout

KW - neurobehavioral variation

KW - risk-taking

KW - sex-differences

KW - wild-type zebrafish

KW - zebrafish

KW - zebrafish danio-rerio

KW - ZEBRAFISH DANIO-RERIO

KW - GENE-ENVIRONMENT INTERACTIONS

KW - ANIMAL-MODELS

KW - Intraspecies variation

KW - WILD-TYPE ZEBRAFISH

KW - JUVENILE RAINBOW-TROUT

KW - RISK-TAKING

KW - Aquatic models

KW - Neurobehavioral variation

KW - Zebrafish

KW - GUT MICROBIOTA

KW - ADULT ZEBRAFISH

KW - INDIVIDUAL-DIFFERENCES

KW - Individuality

KW - SEX-DIFFERENCES

U2 - 10.1016/j.aquatox.2019.02.015

DO - 10.1016/j.aquatox.2019.02.015

M3 - Article

SN - 0166-445X

VL - 210

SP - 44

EP - 55

JO - Aquatic Toxicology

JF - Aquatic Toxicology

ER -

The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models

Abstract

Keywords

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