The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice

Toon J. De Munck, Pan Xu, Brechtje L. J. Vanderfeesten, Montserrat Elizalde, Ad A. M. Masclee, Frederik Nevens, David Cassiman, Frank G. Schaap, Daisy M. A. E. Jonkers, Jef Verbeek*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Brown adipose tissue (BAT) might be a beneficial mediator in the development and treatment of nonalcoholic steatohepatitis (NASH). We aim to evaluate the gene expression of BAT activity-related genes during the development and the dietary and surgical treatment of NASH. BAT was collected from male C57BL/6J mice that received a high fat-high sucrose diet (HF-HSD) or a normal chow diet (NCD) for 4 and 20 weeks (n=8-9 per dietary group and timepoint) and from mice that underwent dietary intervention (return to NCD) (n=8), roux-en-y gastric bypass (RYGB) (n=6), or sham procedure (n=6) after 12 weeks HF-HSD. Expression of BAT genes involved in lipid metabolism (Cd36 and Cpt1b; p

Original languageEnglish
Pages (from-to)869-876
Number of pages8
JournalHormone and Metabolic Research
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • nonalcoholic fatty liver disease
  • NAFLD
  • Nrg4
  • Ucp1
  • obesity
  • FATTY LIVER-DISEASE
  • GASTRIC BYPASS RATS
  • ENERGY-EXPENDITURE
  • INFLAMMATORY MARKERS
  • BARIATRIC SURGERY
  • SKELETAL-MUSCLE
  • NASH
  • STEATOSIS
  • COLD

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