The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice

Toon J. De Munck; Pan Xu; Brechtje L. J. Vanderfeesten; Montserrat Elizalde; Ad A. M. Masclee; Frederik Nevens; David Cassiman; Frank G. Schaap; Daisy M. A. E. Jonkers; Jef Verbeek

doi:10.1055/a-1301-2378

The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice

Toon J. De Munck, Pan Xu, Brechtje L. J. Vanderfeesten, Montserrat Elizalde, Ad A. M. Masclee, Frederik Nevens, David Cassiman, Frank G. Schaap, Daisy M. A. E. Jonkers, Jef Verbeek^*

^*Corresponding author for this work

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Abstract

Brown adipose tissue (BAT) might be a beneficial mediator in the development and treatment of nonalcoholic steatohepatitis (NASH). We aim to evaluate the gene expression of BAT activity-related genes during the development and the dietary and surgical treatment of NASH. BAT was collected from male C57BL/6J mice that received a high fat-high sucrose diet (HF-HSD) or a normal chow diet (NCD) for 4 and 20 weeks (n=8-9 per dietary group and timepoint) and from mice that underwent dietary intervention (return to NCD) (n=8), roux-en-y gastric bypass (RYGB) (n=6), or sham procedure (n=6) after 12 weeks HF-HSD. Expression of BAT genes involved in lipid metabolism (Cd36 and Cpt1b; p

Original language	English
Pages (from-to)	869-876
Number of pages	8
Journal	Hormone and Metabolic Research
Volume	52
Issue number	12
DOIs	https://doi.org/10.1055/a-1301-2378
Publication status	Published - Dec 2020

Keywords

nonalcoholic fatty liver disease
NAFLD
Nrg4
Ucp1
obesity
FATTY LIVER-DISEASE
GASTRIC BYPASS RATS
ENERGY-EXPENDITURE
INFLAMMATORY MARKERS
BARIATRIC SURGERY
SKELETAL-MUSCLE
NASH
STEATOSIS
COLD

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10.1055/a-1301-2378

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De Munck, T. J., Xu, P., Vanderfeesten, B. L. J., Elizalde, M., Masclee, A. A. M., Nevens, F., Cassiman, D., Schaap, F. G., Jonkers, D. M. A. E., & Verbeek, J. (2020). The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice. Hormone and Metabolic Research, 52(12), 869-876. https://doi.org/10.1055/a-1301-2378

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title = "The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice",

abstract = "Brown adipose tissue (BAT) might be a beneficial mediator in the development and treatment of nonalcoholic steatohepatitis (NASH). We aim to evaluate the gene expression of BAT activity-related genes during the development and the dietary and surgical treatment of NASH. BAT was collected from male C57BL/6J mice that received a high fat-high sucrose diet (HF-HSD) or a normal chow diet (NCD) for 4 and 20 weeks (n=8-9 per dietary group and timepoint) and from mice that underwent dietary intervention (return to NCD) (n=8), roux-en-y gastric bypass (RYGB) (n=6), or sham procedure (n=6) after 12 weeks HF-HSD. Expression of BAT genes involved in lipid metabolism (Cd36 and Cpt1b; p",

keywords = "nonalcoholic fatty liver disease, NAFLD, Nrg4, Ucp1, obesity, FATTY LIVER-DISEASE, GASTRIC BYPASS RATS, ENERGY-EXPENDITURE, INFLAMMATORY MARKERS, BARIATRIC SURGERY, SKELETAL-MUSCLE, NASH, STEATOSIS, COLD",

author = "{De Munck}, {Toon J.} and Pan Xu and Vanderfeesten, {Brechtje L. J.} and Montserrat Elizalde and Masclee, {Ad A. M.} and Frederik Nevens and David Cassiman and Schaap, {Frank G.} and Jonkers, {Daisy M. A. E.} and Jef Verbeek",

note = "Funding Information: This research was funded by a seeding grant of the School of Nutrition and Translational Research in Metabolism (NUTRIM), Maas-tricht University, The Netherlands. Publisher Copyright: {\textcopyright} 2020 Georg Thieme Verlag. All rights reserved.",

year = "2020",

month = dec,

doi = "10.1055/a-1301-2378",

language = "English",

volume = "52",

pages = "869--876",

journal = "Hormone and Metabolic Research",

issn = "0018-5043",

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De Munck, TJ, Xu, P, Vanderfeesten, BLJ, Elizalde, M, Masclee, AAM, Nevens, F, Cassiman, D, Schaap, FG , Jonkers, DMAE & Verbeek, J 2020, 'The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis: An Exploratory Gene Expression Study in Mice', Hormone and Metabolic Research, vol. 52, no. 12, pp. 869-876. https://doi.org/10.1055/a-1301-2378

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T1 - The Role of Brown Adipose Tissue in the Development and Treatment of Nonalcoholic Steatohepatitis

T2 - An Exploratory Gene Expression Study in Mice

AU - De Munck, Toon J.

AU - Xu, Pan

AU - Vanderfeesten, Brechtje L. J.

AU - Elizalde, Montserrat

AU - Masclee, Ad A. M.

AU - Nevens, Frederik

AU - Cassiman, David

AU - Schaap, Frank G.

AU - Jonkers, Daisy M. A. E.

AU - Verbeek, Jef

N1 - Funding Information: This research was funded by a seeding grant of the School of Nutrition and Translational Research in Metabolism (NUTRIM), Maas-tricht University, The Netherlands. Publisher Copyright: © 2020 Georg Thieme Verlag. All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Brown adipose tissue (BAT) might be a beneficial mediator in the development and treatment of nonalcoholic steatohepatitis (NASH). We aim to evaluate the gene expression of BAT activity-related genes during the development and the dietary and surgical treatment of NASH. BAT was collected from male C57BL/6J mice that received a high fat-high sucrose diet (HF-HSD) or a normal chow diet (NCD) for 4 and 20 weeks (n=8-9 per dietary group and timepoint) and from mice that underwent dietary intervention (return to NCD) (n=8), roux-en-y gastric bypass (RYGB) (n=6), or sham procedure (n=6) after 12 weeks HF-HSD. Expression of BAT genes involved in lipid metabolism (Cd36 and Cpt1b; p

AB - Brown adipose tissue (BAT) might be a beneficial mediator in the development and treatment of nonalcoholic steatohepatitis (NASH). We aim to evaluate the gene expression of BAT activity-related genes during the development and the dietary and surgical treatment of NASH. BAT was collected from male C57BL/6J mice that received a high fat-high sucrose diet (HF-HSD) or a normal chow diet (NCD) for 4 and 20 weeks (n=8-9 per dietary group and timepoint) and from mice that underwent dietary intervention (return to NCD) (n=8), roux-en-y gastric bypass (RYGB) (n=6), or sham procedure (n=6) after 12 weeks HF-HSD. Expression of BAT genes involved in lipid metabolism (Cd36 and Cpt1b; p

KW - nonalcoholic fatty liver disease

KW - NAFLD

KW - Nrg4

KW - Ucp1

KW - obesity

KW - FATTY LIVER-DISEASE

KW - GASTRIC BYPASS RATS

KW - ENERGY-EXPENDITURE

KW - INFLAMMATORY MARKERS

KW - BARIATRIC SURGERY

KW - SKELETAL-MUSCLE

KW - NASH

KW - STEATOSIS

KW - COLD

U2 - 10.1055/a-1301-2378

DO - 10.1055/a-1301-2378

M3 - Article

C2 - 33260239

SN - 0018-5043

VL - 52

SP - 869

EP - 876

JO - Hormone and Metabolic Research

JF - Hormone and Metabolic Research

IS - 12

ER -