Diagrams and models of biological pathways are useful tools in biology. Pathway diagrams are mainly used for illustrative purposes for instance in textbooks and in presentations. Pathway models are used in the analysis of genomic data. Bridging the gap between diagrams and models allows not only the analysis of genomics data and interactions but also the visualisation of the results in a variety of different ways. The knowledge needed for pathway creation and curation is available from three distinct sources: databases, literature and experts. We describe the role of bioinformatics in facilitating the creation and curation of pathway.