@article{3cb0b92e05b744ccbf13279ac9206c99,
title = "The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)",
abstract = "Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (Significance: Although ovarian cancer is rare, risk of most ovarian cancers doubles as the number of lifetime ovulatory cycles increases from approximately 300 to 500. Thus, identifying an important area for cancer prevention research.",
keywords = "INCESSANT OVULATION, REPRODUCTIVE FACTORS, ORAL-CONTRACEPTIVES, MUTANT P53, OVEREXPRESSION, CARCINOGENESIS, INFLAMMATION, HYPOTHESIS, CARCINOMA, ANDROGENS",
author = "Britton Trabert and Tworoger, {Shelley S.} and O'Brien, {Katie M.} and Townsend, {Mary K.} and Fortner, {Renee T.} and Iversen, {Edwin S.} and Patricia Hartge and Emily White and Pilar Amiano and Arslan, {Alan A.} and Leslie Bernstein and Brinton, {Louise A.} and Buring, {Julie E.} and Laure Dossus and Fraser, {Gary E.} and Gaudet, {Mia M.} and Giles, {Graham G.} and Gram, {Inger T.} and Harris, {Holly R.} and Bolton, {Judith Hoffman} and Annika Idahl and Jones, {Michael E.} and Rudolf Kaaks and Kirsh, {Victoria A.} and Knutsen, {Synnove F.} and Marina Kvaskoff and James Lacey and I-Min Lee and Milne, {Roger L.} and Onland-Moret, {N. Charlotte} and Kim Overvad and Alpa Patel and Ulrike Peters and Poynter, {Jenny N.} and Elio Riboli and Kim Robien and Rohan, {Thomas E.} and Sandler, {Dale P.} and Catherine Schairer and Schouten, {Leo J.} and Setiawan, {Veronica W.} and Swerdlow, {Anthony J.} and Travis, {Ruth C.} and Antonia Trichopoulou and {van den Brandt}, {Piet A.} and Kala Visvanathan and Wilkens, {Lynne R.} and Alicja Wolk and Anne Zeleniuch-Jacquotte and Nicolas Wentzensen and {Ovarian Cancer Cohort Consortium OC3}",
year = "2020",
month = mar,
day = "1",
doi = "10.1158/0008-5472.can-19-2850",
language = "English",
volume = "80",
pages = "1210--1218",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "5",
}