TY - JOUR
T1 - The reproducibility of skeletal muscle signal intensity on routine magnetic resonance imaging in Crohn's disease
AU - Spooren, Corinne E. G. M.
AU - Lodewick, Toine M.
AU - Beelen, Evelien M. J.
AU - van Dijk, David P. J.
AU - Bours, Martijn J. L.
AU - Haans, Jeoffrey J.
AU - Masclee, Ad A. M.
AU - Pierik, Marie J.
AU - Bakers, Frans C. H.
AU - Jonkers, Daisy M. A. E.
N1 - Funding Information:
CS, MP, and DJ report a grant from European commission outside the submitted work. Part of the work of DJ is financed by Grant Top Knowledge Institute (Well on Wheat), the Carbokinietics program as part of the NWO‐CCC Partnership program and H2020 Nr. 848228/DISCOvERIE. The other contributing authors have no conflicts of interest to declare in connection with this paper. Declaration of conflict of interest:
Publisher Copyright:
© 2020 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
PY - 2020/11
Y1 - 2020/11
N2 - Background and Aim Myosteatosis is a prognostic factor in cancer and liver cirrhosis. It can be determined noninvasively using computed tomography or, as shown recently, by magnetic resonance (MR) imaging. The primary aim was to analyze the reproducibility of skeletal muscle signal intensity on routine MR-enterographies, as indicator of myosteatosis, in Crohn's disease (CD) and to explore the association between skeletal muscle signal intensity at diagnosis with time to intestinal resection.Methods CD patients undergoing MR-enterography within 6 months from diagnosis and having a maximum of 5 years follow-up were included. Skeletal muscle signal intensity was analyzed on T1-weighted fat-saturated post-contrast images. Intra-observer and inter-observer reproducibilities were assessed by intra-class correlation coefficient and Cohen's kappa. Intra-observer and inter-observer variabilities were determined by Pearson correlation coefficient and displayed by Bland-Altman plots. Time to intestinal resection was studied by Kaplan-Meier analysis.Results Median time between diagnosis and MR-enterography was 5 weeks (inter-quartile range 1-9) in 35 CD patients. Skeletal muscle signal intensity showed good intra-class correlation and substantial agreement (for intra-observer, intraclass correlation coefficient = 0.948, kappa = 0.677; and inter-observer reproducibility, intraclass correlation coefficient = 0.858, kappa = 0.622). Resection free survival was shorter in the low skeletal muscle signal intensity group (P = 0.037).Conclusion Skeletal muscle signal intensity on routine MR-enterographies is reproducible and was associated with unfavorable disease outcome, indicating potential clinical relevance.
AB - Background and Aim Myosteatosis is a prognostic factor in cancer and liver cirrhosis. It can be determined noninvasively using computed tomography or, as shown recently, by magnetic resonance (MR) imaging. The primary aim was to analyze the reproducibility of skeletal muscle signal intensity on routine MR-enterographies, as indicator of myosteatosis, in Crohn's disease (CD) and to explore the association between skeletal muscle signal intensity at diagnosis with time to intestinal resection.Methods CD patients undergoing MR-enterography within 6 months from diagnosis and having a maximum of 5 years follow-up were included. Skeletal muscle signal intensity was analyzed on T1-weighted fat-saturated post-contrast images. Intra-observer and inter-observer reproducibilities were assessed by intra-class correlation coefficient and Cohen's kappa. Intra-observer and inter-observer variabilities were determined by Pearson correlation coefficient and displayed by Bland-Altman plots. Time to intestinal resection was studied by Kaplan-Meier analysis.Results Median time between diagnosis and MR-enterography was 5 weeks (inter-quartile range 1-9) in 35 CD patients. Skeletal muscle signal intensity showed good intra-class correlation and substantial agreement (for intra-observer, intraclass correlation coefficient = 0.948, kappa = 0.677; and inter-observer reproducibility, intraclass correlation coefficient = 0.858, kappa = 0.622). Resection free survival was shorter in the low skeletal muscle signal intensity group (P = 0.037).Conclusion Skeletal muscle signal intensity on routine MR-enterographies is reproducible and was associated with unfavorable disease outcome, indicating potential clinical relevance.
KW - disease outcome
KW - IBD
KW - myosteatosis
KW - INFLAMMATORY-BOWEL-DISEASE
KW - ADIPOSE-TISSUE VOLUMES
KW - RADIATION ATTENUATION
KW - SURVIVAL
KW - SURGERY
KW - SITE
U2 - 10.1111/jgh.15068
DO - 10.1111/jgh.15068
M3 - Article
C2 - 32267571
SN - 0815-9319
VL - 35
SP - 1902
EP - 1908
JO - Journal of Gastroenterology and Hepatology
JF - Journal of Gastroenterology and Hepatology
IS - 11
ER -