TY - JOUR
T1 - The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis
AU - Smolders, J.
AU - Peelen, E.
AU - Thewissen, M.
AU - Menheere, P.
AU - Tervaert, J.W.
AU - Hupperts, R.
AU - Damoiseaux, J.G.M.C.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - A poor vitamin D status has been associated with several autoimmune diseases, including multiple sclerosis (MS). The receptor for the biologically active metabolite of vitamin D appears to be a key player in these associations, not only as a mediator of the biological effects of vitamin D, but also as a mediator of the regulation of vitamin D metabolism itself. In this concise review, we will discuss the mostly investigated genetic polymorphisms of the vitamin D receptor (VDR), and their consequences for VDR functionality and immune regulation. Next, we will discuss the association of these polymorphisms with MS, and their relation with vitamin D metabolism. We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS.
AB - A poor vitamin D status has been associated with several autoimmune diseases, including multiple sclerosis (MS). The receptor for the biologically active metabolite of vitamin D appears to be a key player in these associations, not only as a mediator of the biological effects of vitamin D, but also as a mediator of the regulation of vitamin D metabolism itself. In this concise review, we will discuss the mostly investigated genetic polymorphisms of the vitamin D receptor (VDR), and their consequences for VDR functionality and immune regulation. Next, we will discuss the association of these polymorphisms with MS, and their relation with vitamin D metabolism. We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS.
U2 - 10.1016/j.autrev.2009.02.009
DO - 10.1016/j.autrev.2009.02.009
M3 - Article
SN - 1568-9972
VL - 8
SP - 621
EP - 626
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 7
ER -