Abstract
Background: Triple X syndrome (47, XXX or trisomy X) is a relatively frequent cytogenetic condition with a large variety of physical and behavioural phenotypes. Method: Two adult patients with a triple X karyotype are described. Results: Their karyotype was unknown until some years ago. What these patients have in common is that they were diagnosed with a broader autism phenotype, they were sexually abused, they suffer from psychotic illness and they show challenging behaviour, suicidality and a decline in occupational capacity. Discussion: These gene-environment interactions are discussed. Gene-environment interactions may explain the variety of behavioural and psychiatric phenotypes in triple X syndrome. Ongoing atypical development in adults is hypothesized. Conclusions: Gene-environment interactions and ongoing atypical development in adults should be taken into account in research concerning the psychiatric phenotype of developmental disorders, especially those involving triple X syndrome.
Original language | English |
---|---|
Pages (from-to) | 233-238 |
Journal | Developmental Neurorehabilitation |
Volume | 15 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Triple X syndrome
- behavioural phenotype
- development in adults
- occupational development
- sexual trauma
- autism spectrum disorders