The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies

L. Poller; S. Ibrahim; M. Keown; A. Pattison; J. Jespersen; S. Marun; W. Muntean; Gerold Aspoeck; Alex S. Gallus; E. Bailleul; William Wijns; T. Michel; Kristin Jochmans; B. Chatelain; Carlo L. M. Marcelis; A.S. Nijs de; M. Johnston; K. Kynde; M. Syrjala; E.-R. Savolainen; K. Ivaska; A. Rajamaki; R. Vanharanta; I. Juhan; M.-F. Aillaud; M.-C. Guillin; M.-G. Huisse; P. Sie; T. Lecompte; Y. Schmitt; J. Harenberg; W. Plesch; S. Aronis; George Theodossiades; B. Tsoukanas; D. Markala; M. Ditsa; M. Cahill; M. Madden; B. White; B.T. Nolan; H. Fitzgerald; D. McCarthy; B. Collins; S. Rooney; E. Naparstek; G. Palareti; F. Marongiu; N. Erba; Sophie Testa; G. Mariani; R. Poti; P. M. Mannucci; A. Tripodi; R. Bader; Vittorio Pengo; Paolo Gresele; Marco D'inca; W. Ageno; Alberto Tosetto; H. E. S. J. Hensgens; R. N. Idema; D. H. Oosterhout; A. B. Mulder; K. Hamulyak; H. van der Dussen; J. Musial; T. Gago; A. Palmeiro; Manuel Campos; D. A. Marques-Dias; A. Cunha Monteiro; M. Angela Cunha; W. N. de Gaia; P. Peternel; M. Stegnar; J. Fontcuberta; M. Borrell; J. C. Reverter; P. Domenech Santasusana; M. Fernanda Lopez-Fernandez; José Luis Castro-Montero; C. Ribera Casado; Vicente Vicente; B. Edlund; N. Egberg; B. Laemmle; L. Alberio; P. de Moerloose; G. Reber; S. J. Machin; I. Mackie; A. Lawrie; J. Luckit; D. Shanks; G. Dolan; T. Flaherty; C. A. Ludlam; I. D. Walker; D. E. Lawson; M. Triscott; R. A. Marlar; J. A. Heit; H. Watzke; B. Weisser; J. Osmond; I. Cornet; A.-M. Munster; B. Leed; C. Chillou; M. Defard; M. H. Horellou; H. Halkin; R. Loebstein; I. Kirgner; F. Dentali; V. Trapani Lombardo; Gianluca Sottilotta; P. Consiglio; S. De Michele; M. Moia; Monica Carpenedo; C. Manotti; M. Ilaria Tassoni; B. Cosmi; C. Brusi; C. Legnani; C. Pegoraro; C. Andriani; M. Grazia Cirigliano; E. Ribaldi; R. Abbate; D. Poli; C. Perricone; M. Schiavuli; C. Casiera; M. R. Lupone; Emanuela Rossi; S. Crivelli; A. Birolini; F. Parente; A. M. Miglietta; M. Campobasso; W. Sydor; B. Krevel; T. M. A. Fernandez; Andres M. Lozano; C. Shiach; C. Bowyer; F. Charles

doi:10.1111/j.1538-7836.2010.04109.x

The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies

L. Poller^*, S. Ibrahim, M. Keown, A. Pattison, J. Jespersen, S. Marun, W. Muntean, Gerold Aspoeck, Alex S. Gallus, E. Bailleul, William Wijns, T. Michel, Kristin Jochmans, B. Chatelain, Carlo L. M. Marcelis, A.S. Nijs de, M. Johnston, K. Kynde, M. Syrjala, E.-R. SavolainenK. Ivaska, A. Rajamaki, R. Vanharanta, I. Juhan, M.-F. Aillaud, M.-C. Guillin, M.-G. Huisse, P. Sie, T. Lecompte, Y. Schmitt, J. Harenberg, W. Plesch, S. Aronis, George Theodossiades, B. Tsoukanas, D. Markala, M. Ditsa, M. Cahill, M. Madden, B. White, B.T. Nolan, H. Fitzgerald, D. McCarthy, B. Collins, S. Rooney, E. Naparstek, G. Palareti, F. Marongiu, N. Erba, Sophie Testa, G. Mariani, R. Poti, P. M. Mannucci, A. Tripodi, R. Bader, Vittorio Pengo, Paolo Gresele, Marco D'inca, W. Ageno, Alberto Tosetto, H. E. S. J. Hensgens, R. N. Idema, D. H. Oosterhout, A. B. Mulder, K. Hamulyak, H. van der Dussen, J. Musial, T. Gago, A. Palmeiro, Manuel Campos, D. A. Marques-Dias, A. Cunha Monteiro, M. Angela Cunha, W. N. de Gaia, P. Peternel, M. Stegnar, J. Fontcuberta, M. Borrell, J. C. Reverter, P. Domenech Santasusana, M. Fernanda Lopez-Fernandez, José Luis Castro-Montero, C. Ribera Casado, Vicente Vicente, B. Edlund, N. Egberg, B. Laemmle, L. Alberio, P. de Moerloose, G. Reber, S. J. Machin, I. Mackie, A. Lawrie, J. Luckit, D. Shanks, G. Dolan, T. Flaherty, C. A. Ludlam, I. D. Walker, D. E. Lawson, M. Triscott, R. A. Marlar, J. A. Heit, H. Watzke, B. Weisser, J. Osmond, I. Cornet, A.-M. Munster, B. Leed, C. Chillou, M. Defard, M. H. Horellou, H. Halkin, R. Loebstein, I. Kirgner, F. Dentali, V. Trapani Lombardo, Gianluca Sottilotta, P. Consiglio, S. De Michele, M. Moia, Monica Carpenedo, C. Manotti, M. Ilaria Tassoni, B. Cosmi, C. Brusi, C. Legnani, C. Pegoraro, C. Andriani, M. Grazia Cirigliano, E. Ribaldi, R. Abbate, D. Poli, C. Perricone, M. Schiavuli, C. Casiera, M. R. Lupone, Emanuela Rossi, S. Crivelli, A. Birolini, F. Parente, A. M. Miglietta, M. Campobasso, W. Sydor, B. Krevel, T. M. A. Fernandez, Andres M. Lozano, C. Shiach, C. Bowyer, F. Charles

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The WHO scheme for prothrombin time (PT) standardization has been limited in application, because of its difficulties in implementation, particularly the need for mandatory manual PT testing and for local provision of thromboplastin international reference preparations (IRP).The value of a new simpler procedure to derive international normalized ratio (INR), the PT/INR Line, based on only five European Concerted Action on Anticoagulation (ECAA) calibrant plasmas certified by experienced centres has been assessed in two independent exercises using a range of commercial thromboplastins and coagulometers. INRs were compared with manual certified values with thromboplastin IRP from expert centres and in the second study also with INRs from local ISI calibrations.In the first study with the PT/INR Line, 8.7% deviation from certified INRs was reduced to 1.1% with human reagents, and from 7.0% to 2.6% with rabbit reagents. In the second study, deviation was reduced from 11.2% to 0.4% with human reagents by both local ISI calibration and the PT/INR Line. With rabbit reagents, 10.4% deviation was reduced to 1.1% with both procedures; 4.9% deviation was reduced to 0.5% with bovine/combined reagents with local ISI calibrations and to 2.9% with the PT/INR Line. Mean INR dispersion was reduced with all thromboplastins and automated systems using the PT/INR Line.The procedure using the PT/INR Line provides reliable INR derivation without the need for WHO ISI calibration across the range of locally used commercial thromboplastins and automated PT systems included in two independent international studies.? 2010 International Society on Thrombosis and Haemostasis.

Original language	English
Pages (from-to)	140-148
Journal	Journal of Thrombosis and Haemostasis
Volume	9
Issue number	1
DOIs	https://doi.org/10.1111/j.1538-7836.2010.04109.x
Publication status	Published - Jan 2011

Keywords

coagulometers
ECAA plasmas
INR correction
prothrombin time
PT
INR Line
thromboplastins

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10.1111/j.1538-7836.2010.04109.x

Cite this

Poller, L., Ibrahim, S., Keown, M., Pattison, A., Jespersen, J., Marun, S., Muntean, W., Aspoeck, G., Gallus, A. S., Bailleul, E., Wijns, W., Michel, T., Jochmans, K., Chatelain, B., Marcelis, C. L. M., Nijs de, A. S., Johnston, M., Kynde, K., Syrjala, M., ... Charles, F. (2011). The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies. Journal of Thrombosis and Haemostasis, 9(1), 140-148. https://doi.org/10.1111/j.1538-7836.2010.04109.x

@article{c76cb9c6d86d4e3ea52005934e9e5c52,

title = "The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies",

abstract = "The WHO scheme for prothrombin time (PT) standardization has been limited in application, because of its difficulties in implementation, particularly the need for mandatory manual PT testing and for local provision of thromboplastin international reference preparations (IRP).The value of a new simpler procedure to derive international normalized ratio (INR), the PT/INR Line, based on only five European Concerted Action on Anticoagulation (ECAA) calibrant plasmas certified by experienced centres has been assessed in two independent exercises using a range of commercial thromboplastins and coagulometers. INRs were compared with manual certified values with thromboplastin IRP from expert centres and in the second study also with INRs from local ISI calibrations.In the first study with the PT/INR Line, 8.7% deviation from certified INRs was reduced to 1.1% with human reagents, and from 7.0% to 2.6% with rabbit reagents. In the second study, deviation was reduced from 11.2% to 0.4% with human reagents by both local ISI calibration and the PT/INR Line. With rabbit reagents, 10.4% deviation was reduced to 1.1% with both procedures; 4.9% deviation was reduced to 0.5% with bovine/combined reagents with local ISI calibrations and to 2.9% with the PT/INR Line. Mean INR dispersion was reduced with all thromboplastins and automated systems using the PT/INR Line.The procedure using the PT/INR Line provides reliable INR derivation without the need for WHO ISI calibration across the range of locally used commercial thromboplastins and automated PT systems included in two independent international studies.? 2010 International Society on Thrombosis and Haemostasis.",

keywords = "coagulometers, ECAA plasmas, INR correction, prothrombin time, PT, INR Line, thromboplastins",

author = "L. Poller and S. Ibrahim and M. Keown and A. Pattison and J. Jespersen and S. Marun and W. Muntean and Gerold Aspoeck and Gallus, {Alex S.} and E. Bailleul and William Wijns and T. Michel and Kristin Jochmans and B. Chatelain and Marcelis, {Carlo L. M.} and {Nijs de}, A.S. and M. Johnston and K. Kynde and M. Syrjala and E.-R. Savolainen and K. Ivaska and A. Rajamaki and R. Vanharanta and I. Juhan and M.-F. Aillaud and M.-C. Guillin and M.-G. Huisse and P. Sie and T. Lecompte and Y. Schmitt and J. Harenberg and W. Plesch and S. Aronis and George Theodossiades and B. Tsoukanas and D. Markala and M. Ditsa and M. Cahill and M. Madden and B. White and B.T. Nolan and H. Fitzgerald and D. McCarthy and B. Collins and S. Rooney and E. Naparstek and G. Palareti and F. Marongiu and N. Erba and Sophie Testa and G. Mariani and R. Poti and Mannucci, {P. M.} and A. Tripodi and R. Bader and Vittorio Pengo and Paolo Gresele and Marco D'inca and W. Ageno and Alberto Tosetto and Hensgens, {H. E. S. J.} and Idema, {R. N.} and Oosterhout, {D. H.} and Mulder, {A. B.} and K. Hamulyak and {van der Dussen}, H. and J. Musial and T. Gago and A. Palmeiro and Manuel Campos and Marques-Dias, {D. A.} and Monteiro, {A. Cunha} and Cunha, {M. Angela} and {de Gaia}, {W. N.} and P. Peternel and M. Stegnar and J. Fontcuberta and M. Borrell and Reverter, {J. C.} and Santasusana, {P. Domenech} and Lopez-Fernandez, {M. Fernanda} and Castro-Montero, {Jos{\'e} Luis} and {Ribera Casado}, C. and Vicente Vicente and B. Edlund and N. Egberg and B. Laemmle and L. Alberio and {de Moerloose}, P. and G. Reber and Machin, {S. J.} and I. Mackie and A. Lawrie and J. Luckit and D. Shanks and G. Dolan and T. Flaherty and Ludlam, {C. A.} and Walker, {I. D.} and Lawson, {D. E.} and M. Triscott and Marlar, {R. A.} and Heit, {J. A.} and H. Watzke and B. Weisser and J. Osmond and I. Cornet and A.-M. Munster and B. Leed and C. Chillou and M. Defard and Horellou, {M. H.} and H. Halkin and R. Loebstein and I. Kirgner and F. Dentali and {Trapani Lombardo}, V. and Gianluca Sottilotta and P. Consiglio and {De Michele}, S. and M. Moia and Monica Carpenedo and C. Manotti and Tassoni, {M. Ilaria} and B. Cosmi and C. Brusi and C. Legnani and C. Pegoraro and C. Andriani and {Grazia Cirigliano}, M. and E. Ribaldi and R. Abbate and D. Poli and C. Perricone and M. Schiavuli and C. Casiera and Lupone, {M. R.} and Emanuela Rossi and S. Crivelli and A. Birolini and F. Parente and Miglietta, {A. M.} and M. Campobasso and W. Sydor and B. Krevel and Fernandez, {T. M. A.} and Lozano, {Andres M.} and C. Shiach and C. Bowyer and F. Charles",

year = "2011",

month = jan,

doi = "10.1111/j.1538-7836.2010.04109.x",

language = "English",

volume = "9",

pages = "140--148",

journal = "Journal of Thrombosis and Haemostasis",

issn = "1538-7933",

publisher = "Elsevier B.V.",

number = "1",

}

Poller, L, Ibrahim, S, Keown, M, Pattison, A, Jespersen, J, Marun, S, Muntean, W, Aspoeck, G, Gallus, AS, Bailleul, E, Wijns, W, Michel, T, Jochmans, K, Chatelain, B, Marcelis, CLM, Nijs de, AS, Johnston, M, Kynde, K, Syrjala, M, Savolainen, E-R, Ivaska, K, Rajamaki, A, Vanharanta, R, Juhan, I, Aillaud, M-F, Guillin, M-C, Huisse, M-G, Sie, P, Lecompte, T, Schmitt, Y, Harenberg, J, Plesch, W, Aronis, S, Theodossiades, G, Tsoukanas, B, Markala, D, Ditsa, M, Cahill, M, Madden, M, White, B, Nolan, BT, Fitzgerald, H, McCarthy, D, Collins, B, Rooney, S, Naparstek, E, Palareti, G, Marongiu, F, Erba, N, Testa, S, Mariani, G, Poti, R, Mannucci, PM, Tripodi, A, Bader, R, Pengo, V, Gresele, P, D'inca, M, Ageno, W, Tosetto, A, Hensgens, HESJ, Idema, RN, Oosterhout, DH, Mulder, AB, Hamulyak, K, van der Dussen, H, Musial, J, Gago, T, Palmeiro, A, Campos, M, Marques-Dias, DA, Monteiro, AC, Cunha, MA, de Gaia, WN, Peternel, P, Stegnar, M, Fontcuberta, J, Borrell, M, Reverter, JC, Santasusana, PD, Lopez-Fernandez, MF, Castro-Montero, JL, Ribera Casado, C, Vicente, V, Edlund, B, Egberg, N, Laemmle, B, Alberio, L, de Moerloose, P, Reber, G, Machin, SJ, Mackie, I, Lawrie, A, Luckit, J, Shanks, D, Dolan, G, Flaherty, T, Ludlam, CA, Walker, ID, Lawson, DE, Triscott, M, Marlar, RA, Heit, JA, Watzke, H, Weisser, B, Osmond, J, Cornet, I, Munster, A-M, Leed, B, Chillou, C, Defard, M, Horellou, MH, Halkin, H, Loebstein, R, Kirgner, I, Dentali, F, Trapani Lombardo, V, Sottilotta, G, Consiglio, P, De Michele, S, Moia, M, Carpenedo, M, Manotti, C, Tassoni, MI, Cosmi, B, Brusi, C, Legnani, C, Pegoraro, C, Andriani, C, Grazia Cirigliano, M, Ribaldi, E, Abbate, R, Poli, D, Perricone, C, Schiavuli, M, Casiera, C, Lupone, MR, Rossi, E, Crivelli, S, Birolini, A, Parente, F, Miglietta, AM, Campobasso, M, Sydor, W, Krevel, B, Fernandez, TMA, Lozano, AM, Shiach, C, Bowyer, C & Charles, F 2011, 'The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies', Journal of Thrombosis and Haemostasis, vol. 9, no. 1, pp. 140-148. https://doi.org/10.1111/j.1538-7836.2010.04109.x

The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies. / Poller, L.; Ibrahim, S.; Keown, M. et al.
In: Journal of Thrombosis and Haemostasis, Vol. 9, No. 1, 01.2011, p. 140-148.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies

AU - Poller, L.

AU - Ibrahim, S.

AU - Keown, M.

AU - Pattison, A.

AU - Jespersen, J.

AU - Marun, S.

AU - Muntean, W.

AU - Aspoeck, Gerold

AU - Gallus, Alex S.

AU - Bailleul, E.

AU - Wijns, William

AU - Michel, T.

AU - Jochmans, Kristin

AU - Chatelain, B.

AU - Marcelis, Carlo L. M.

AU - Nijs de, A.S.

AU - Johnston, M.

AU - Kynde, K.

AU - Syrjala, M.

AU - Savolainen, E.-R.

AU - Ivaska, K.

AU - Rajamaki, A.

AU - Vanharanta, R.

AU - Juhan, I.

AU - Aillaud, M.-F.

AU - Guillin, M.-C.

AU - Huisse, M.-G.

AU - Sie, P.

AU - Lecompte, T.

AU - Schmitt, Y.

AU - Harenberg, J.

AU - Plesch, W.

AU - Aronis, S.

AU - Theodossiades, George

AU - Tsoukanas, B.

AU - Markala, D.

AU - Ditsa, M.

AU - Cahill, M.

AU - Madden, M.

AU - White, B.

AU - Nolan, B.T.

AU - Fitzgerald, H.

AU - McCarthy, D.

AU - Collins, B.

AU - Rooney, S.

AU - Naparstek, E.

AU - Palareti, G.

AU - Marongiu, F.

AU - Erba, N.

AU - Testa, Sophie

AU - Mariani, G.

AU - Poti, R.

AU - Mannucci, P. M.

AU - Tripodi, A.

AU - Bader, R.

AU - Pengo, Vittorio

AU - Gresele, Paolo

AU - D'inca, Marco

AU - Ageno, W.

AU - Tosetto, Alberto

AU - Hensgens, H. E. S. J.

AU - Idema, R. N.

AU - Oosterhout, D. H.

AU - Mulder, A. B.

AU - Hamulyak, K.

AU - van der Dussen, H.

AU - Musial, J.

AU - Gago, T.

AU - Palmeiro, A.

AU - Campos, Manuel

AU - Marques-Dias, D. A.

AU - Monteiro, A. Cunha

AU - Cunha, M. Angela

AU - de Gaia, W. N.

AU - Peternel, P.

AU - Stegnar, M.

AU - Fontcuberta, J.

AU - Borrell, M.

AU - Reverter, J. C.

AU - Santasusana, P. Domenech

AU - Lopez-Fernandez, M. Fernanda

AU - Castro-Montero, José Luis

AU - Ribera Casado, C.

AU - Vicente, Vicente

AU - Edlund, B.

AU - Egberg, N.

AU - Laemmle, B.

AU - Alberio, L.

AU - de Moerloose, P.

AU - Reber, G.

AU - Machin, S. J.

AU - Mackie, I.

AU - Lawrie, A.

AU - Luckit, J.

AU - Shanks, D.

AU - Dolan, G.

AU - Flaherty, T.

AU - Ludlam, C. A.

AU - Walker, I. D.

AU - Lawson, D. E.

AU - Triscott, M.

AU - Marlar, R. A.

AU - Heit, J. A.

AU - Watzke, H.

AU - Weisser, B.

AU - Osmond, J.

AU - Cornet, I.

AU - Munster, A.-M.

AU - Leed, B.

AU - Chillou, C.

AU - Defard, M.

AU - Horellou, M. H.

AU - Halkin, H.

AU - Loebstein, R.

AU - Kirgner, I.

AU - Dentali, F.

AU - Trapani Lombardo, V.

AU - Sottilotta, Gianluca

AU - Consiglio, P.

AU - De Michele, S.

AU - Moia, M.

AU - Carpenedo, Monica

AU - Manotti, C.

AU - Tassoni, M. Ilaria

AU - Cosmi, B.

AU - Brusi, C.

AU - Legnani, C.

AU - Pegoraro, C.

AU - Andriani, C.

AU - Grazia Cirigliano, M.

AU - Ribaldi, E.

AU - Abbate, R.

AU - Poli, D.

AU - Perricone, C.

AU - Schiavuli, M.

AU - Casiera, C.

AU - Lupone, M. R.

AU - Rossi, Emanuela

AU - Crivelli, S.

AU - Birolini, A.

AU - Parente, F.

AU - Miglietta, A. M.

AU - Campobasso, M.

AU - Sydor, W.

AU - Krevel, B.

AU - Fernandez, T. M. A.

AU - Lozano, Andres M.

AU - Shiach, C.

AU - Bowyer, C.

AU - Charles, F.

PY - 2011/1

Y1 - 2011/1

N2 - The WHO scheme for prothrombin time (PT) standardization has been limited in application, because of its difficulties in implementation, particularly the need for mandatory manual PT testing and for local provision of thromboplastin international reference preparations (IRP).The value of a new simpler procedure to derive international normalized ratio (INR), the PT/INR Line, based on only five European Concerted Action on Anticoagulation (ECAA) calibrant plasmas certified by experienced centres has been assessed in two independent exercises using a range of commercial thromboplastins and coagulometers. INRs were compared with manual certified values with thromboplastin IRP from expert centres and in the second study also with INRs from local ISI calibrations.In the first study with the PT/INR Line, 8.7% deviation from certified INRs was reduced to 1.1% with human reagents, and from 7.0% to 2.6% with rabbit reagents. In the second study, deviation was reduced from 11.2% to 0.4% with human reagents by both local ISI calibration and the PT/INR Line. With rabbit reagents, 10.4% deviation was reduced to 1.1% with both procedures; 4.9% deviation was reduced to 0.5% with bovine/combined reagents with local ISI calibrations and to 2.9% with the PT/INR Line. Mean INR dispersion was reduced with all thromboplastins and automated systems using the PT/INR Line.The procedure using the PT/INR Line provides reliable INR derivation without the need for WHO ISI calibration across the range of locally used commercial thromboplastins and automated PT systems included in two independent international studies.? 2010 International Society on Thrombosis and Haemostasis.

AB - The WHO scheme for prothrombin time (PT) standardization has been limited in application, because of its difficulties in implementation, particularly the need for mandatory manual PT testing and for local provision of thromboplastin international reference preparations (IRP).The value of a new simpler procedure to derive international normalized ratio (INR), the PT/INR Line, based on only five European Concerted Action on Anticoagulation (ECAA) calibrant plasmas certified by experienced centres has been assessed in two independent exercises using a range of commercial thromboplastins and coagulometers. INRs were compared with manual certified values with thromboplastin IRP from expert centres and in the second study also with INRs from local ISI calibrations.In the first study with the PT/INR Line, 8.7% deviation from certified INRs was reduced to 1.1% with human reagents, and from 7.0% to 2.6% with rabbit reagents. In the second study, deviation was reduced from 11.2% to 0.4% with human reagents by both local ISI calibration and the PT/INR Line. With rabbit reagents, 10.4% deviation was reduced to 1.1% with both procedures; 4.9% deviation was reduced to 0.5% with bovine/combined reagents with local ISI calibrations and to 2.9% with the PT/INR Line. Mean INR dispersion was reduced with all thromboplastins and automated systems using the PT/INR Line.The procedure using the PT/INR Line provides reliable INR derivation without the need for WHO ISI calibration across the range of locally used commercial thromboplastins and automated PT systems included in two independent international studies.? 2010 International Society on Thrombosis and Haemostasis.

KW - coagulometers

KW - ECAA plasmas

KW - INR correction

KW - prothrombin time

KW - PT

KW - INR Line

KW - thromboplastins

U2 - 10.1111/j.1538-7836.2010.04109.x

DO - 10.1111/j.1538-7836.2010.04109.x

M3 - Article

C2 - 20942851

SN - 1538-7933

VL - 9

SP - 140

EP - 148

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 1

ER -

The prothrombin time/international normalized ratio (PT/INR) Line: derivation of local INR with commercial thromboplastins and coagulometers - two independent studies

Abstract

Keywords

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