The procoagulant effects of fine particulate matter in vivo

Evren Kilinc; Holger Schulz; Gerhardus J. A. J. M. Kuiper; Henri M. H. Spronk; Hugo ten Cate; Swapna Upadhyay; Koustav Ganguly; Tobias Stoeger; Manuela Semmler-Bhenke; Shinji Takenaka; Wolfgang G. Kreyling; Mike Pitz; Peter Reitmeir; Annette Peters; Oliver Eickelberg; H Erich Wichmann

doi:10.1186/1743-8977-8-12

The procoagulant effects of fine particulate matter in vivo

Evren Kilinc^*, Holger Schulz, Gerhardus J. A. J. M. Kuiper, Henri M. H. Spronk, Hugo ten Cate, Swapna Upadhyay, Koustav Ganguly, Tobias Stoeger, Manuela Semmler-Bhenke, Shinji Takenaka, Wolfgang G. Kreyling, Mike Pitz, Peter Reitmeir, Annette Peters, Oliver Eickelberg, H Erich Wichmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Inhalation of fine particulate matter (<2.5 mu m; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.

Original language	English
Pages (from-to)	3
Journal	Particle and Fibre Toxicology
Volume	8
DOIs	https://doi.org/10.1186/1743-8977-8-12
Publication status	Published - 15 Mar 2011

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10.1186/1743-8977-8-12Licence: CC BY

Cite this

Kilinc, E., Schulz, H., Kuiper, G. J. A. J. M., Spronk, H. M. H., ten Cate, H., Upadhyay, S., Ganguly, K., Stoeger, T., Semmler-Bhenke, M., Takenaka, S., Kreyling, W. G., Pitz, M., Reitmeir, P., Peters, A., Eickelberg, O., & Wichmann, H. E. (2011). The procoagulant effects of fine particulate matter in vivo. Particle and Fibre Toxicology, 8, 3. https://doi.org/10.1186/1743-8977-8-12

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title = "The procoagulant effects of fine particulate matter in vivo",

abstract = "Inhalation of fine particulate matter (<2.5 mu m; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.",

author = "Evren Kilinc and Holger Schulz and Kuiper, {Gerhardus J. A. J. M.} and Spronk, {Henri M. H.} and {ten Cate}, Hugo and Swapna Upadhyay and Koustav Ganguly and Tobias Stoeger and Manuela Semmler-Bhenke and Shinji Takenaka and Kreyling, {Wolfgang G.} and Mike Pitz and Peter Reitmeir and Annette Peters and Oliver Eickelberg and Wichmann, {H Erich}",

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doi = "10.1186/1743-8977-8-12",

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T1 - The procoagulant effects of fine particulate matter in vivo

AU - Kilinc, Evren

AU - Schulz, Holger

AU - Kuiper, Gerhardus J. A. J. M.

AU - Spronk, Henri M. H.

AU - ten Cate, Hugo

AU - Upadhyay, Swapna

AU - Ganguly, Koustav

AU - Stoeger, Tobias

AU - Semmler-Bhenke, Manuela

AU - Takenaka, Shinji

AU - Kreyling, Wolfgang G.

AU - Pitz, Mike

AU - Reitmeir, Peter

AU - Peters, Annette

AU - Eickelberg, Oliver

AU - Wichmann, H Erich

PY - 2011/3/15

Y1 - 2011/3/15

N2 - Inhalation of fine particulate matter (<2.5 mu m; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.

AB - Inhalation of fine particulate matter (<2.5 mu m; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.

U2 - 10.1186/1743-8977-8-12

DO - 10.1186/1743-8977-8-12

M3 - Article

C2 - 21406084

SN - 1743-8977

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SP - 3

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

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