The prevalence of the Staphylococcus aureus tst gene among community- and hospital-acquired strains and isolates from Wegener's Granulomatosis patients

R.H.C.A. Deurenberg, R.F. Nieuwenhuis, C.C. Driessen, N. London, F.R. Stassen, F.H. van Tiel, E.E. Stobberingh, C. Vink*

*Corresponding author for this work

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To allow rapid identification of toxic shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus strains, a real-time PCR assay for the detection of the tst gene, which encodes TSST-1, was developed. The assay was applied to S. aureus isolates from patients with Wegener's Granulomatosis (WG), as well as isolates that were classified as either community- (CA) or hospital-acquired (HA). No significant difference in the percentage of tst-positive strains was observed between isolates from WG patients and CA isolates (24% and 25%, respectively). In contrast, only 14% of the HA isolates were tst-positive (p<0.05). Investigation of the clonal relationship between tst-positive CA and HA strains could indicated the recent emergence of a virulent S. aureus clone in the community.
Original languageEnglish
Pages (from-to)185-189
JournalFems Microbiology Letters
Issue number1
Publication statusPublished - 1 Jan 2005

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