The potential of adipokines in identifying multiple trauma patients at risk of developing multiple organ dysfunction syndrome

Julian Haupt*, Niels Krysiak, Marina Unger, Viktoria Bogner-Flatz, Peter Biberthaler, Marc Hanschen, Martijn van Griensven, Alexander T Haug

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)


BACKGROUND: Multiple organ dysfunction syndrome (MODS) and the consecutive multiple organ failure (MOF) are severe and dreaded complications with a high mortality in multiple trauma patients. The aim of this study was to investigate the potential of the adipokines leptin, resistin, interleukin-17A and interleukin-33 as possible biomarkers in the early posttraumatic inflammatory response and for identifying severely traumatized patients at risk of developing MODS.

METHODS: In total, 14 multiple trauma patients with an injury severity score (ISS) ≥ 16 as well as a control group of 14 non-multiple trauma patients were included in this study and blood samples were taken at the time points 0, 6, 24, 48 and 72 h after admission. For the trauma patients, the SIRS and Denver MOF score were determined daily. The quantitative measurement of the plasma concentrations of the adipokines was performed using ELISA.

RESULTS: In the statistical analysis, the multiple trauma patients showed statistically significant higher plasma concentrations of leptin, resistin, IL-17A and IL-33 compared to the control group. In addition, there was a statistically significant positive correlation between the concentrations of resistin, IL-17A and IL-33 and the corresponding SIRS scores and between the concentrations of resistin, IL-17A and IL-33 and the corresponding Denver MOF scores. Finally, ROC curve analysis revealed that the adipokines leptin and IL-17A are suitable diagnostic markers for the discrimination between multiple trauma patients with and without MOF.

CONCLUSIONS: Leptin and IL-17A could be suitable diagnostic markers to identify severely injured patients with a developing SIRS and MOF earlier, to adjust surgical therapy planning and intensive care.

Original languageEnglish
Article number38
Pages (from-to)38
Number of pages10
JournalEuropean Journal of Medical Research
Issue number1
Publication statusPublished - 30 Apr 2021


  • Multiple trauma
  • Multiple organ dysfunction syndrome
  • Multiple organ failure
  • Adipokines
  • Leptin
  • Resistin
  • Interleukin-17A
  • Interleukin-33
  • IL-33

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