The POSE-2 Procedure for People with Obesity: A Safe and Effective Treatment Option

Marijn T. F. Jense*, Tymen Hodde, Inge H. Palm-Meinders, Paul H. A. Bours, Khalida Soufidi, Evert-Jan G. Boerma, Jan Willem M. Greve

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose Besides lifestyle interventions, medication, and surgery, endoscopic options are becoming part of the current treatment landscape for people with obesity. With the POSE (Primary Obesity Surgery Endoscopic) procedure, endoluminal folds are created in the stomach with full-thickness sutures. Recently, the modified version, POSE-2, was introduced in clinical practice. This study aims to evaluate the safety and effectiveness of the POSE-2 procedure after one year in patients with obesity. Materials and Methods All patients treated with the POSE-2 procedure between March 2019 and November 2022 in the Zuyderland Medical Center and the Dutch Obesity Clinic were included in this retrospective data study. Inclusion criteria are as follows: age between 18 and 65 years and a BMI > 30 kg/m(2). All patients with contraindications for the POSE-2 procedure were excluded. Results Forty-nine patients were included of which 86% were female, with a mean age of 46 years and mean BMI of 34.6 kg/m(2). Total weight loss was evaluated at 3, 6, and 12 months and was 11.5%, 13.2%, and 14.8%, respectively. A median of 14 anchor sutures was used in a median procedure time of 50 min. All patients except one had same day discharge. Postprocedural complaints were mild and consisted of nausea and vomiting (36.7%) and pain (54.2%). No complications were recorded in this group. One week postprocedure, most patients (95.9%) reported feeling satisfied between meals. Conclusion The POSE-2 procedure can be applied as a safe and effective treatment for people with obesity. This study presents a positive effect on weight reduction and no complications after 1 year of follow-up.
Original languageEnglish
Number of pages8
JournalObesity Surgery
Issue number10
DOIs
Publication statusPublished - 1 Sept 2024

Keywords

  • POSE-2 procedure
  • Bariatric treatment
  • Lifestyle intervention
  • Obesity
  • Weight loss
  • Endoscopic treatment
  • WEIGHT-LOSS
  • SURGERY

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