The portal-drained viscera release fibroblast growth factor 19 in humans

Kiran V. K. Koelfat*, Johanne G. Bloemen, Peter Jansen, Kees Dejong, Frank G. Schaap, Steven W. M. Olde Damink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

Fibroblast growth factor 19 (FGF19) is an ileum-derived endrocrine factor that is produced in response to transepithelial bile salt flux. FGF19 represses bile salt synthesis in the liver. Despite the general assumption that FGF19 signals to the liver via portal blood, no human data are available to support this notion. The aim was to study portal FGF19 levels, and determined bile salt and FGF19 fluxes across visceral organs in humans. Bile salt and FGF19 levels were assessed in arterial, portal, and hepatic venous blood collected from fasted patients who underwent partial liver resection for colorectal liver metastases (n=30). Fluxes across the portal-drained viscera (PDV), liver, and splanchnic area were calculated. Portal bile salt levels (7.8 [5.0-12.4] mol/L) were higher than levels in arterial (2.7 [1.7-5.5] mol/L, P
Original languageEnglish
JournalPhysiological Reports
Volume4
Issue number24
DOIs
Publication statusPublished - Dec 2016

Keywords

  • bile salts
  • entero-hepatic circulation
  • FGF19
  • organ fluxes

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