The Physiology of weight loss and weight regain in overweight humans

Roel Vink

Research output: ThesisDoctoral ThesisInternal


Weight loss can be achieved easily with dietary intervention, but many people will soon gain that weight back again (the yo-yo effect). Research is needed to identify the causes of this regained weight. This PhD dissertation describes the physiology of weight loss and seeks to identify causes of the yo-yo effect. Contrary to dietary guidelines in various countries, it appears that losing weight quickly (‘crash dieting’) does not lead to faster weight gain afterward than slower weight loss when tracked over a nine-month follow-up period. The rate of weight loss does influence the gene expression of fat cells, which could possibly lead to functional effects. It also appears that higher loss of muscle mass during a diet is related to weight gain during follow-up. Finally, three biomarkers were found that can predict the yo-yo effect to a certain extent.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • van Baak, Marleen, Supervisor
  • Mariman, Edwin, Supervisor
Award date11 Nov 2016
Publication statusPublished - 2016


  • weight loss
  • yo-yo effect
  • physiology
  • biomarkers

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