The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity

Ligia Mendes Soares, Erika Meyer, Humberto Milani, Harry W. M. Steinbusch, Jos Prickaerts, Rubia M. Weffort de Oliveira*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)510-520
Number of pages11
JournalEuropean Journal of Neuroscience
Volume45
Issue number4
DOIs
Publication statusPublished - Feb 2017

Keywords

  • antidepressant
  • anxiolytic
  • cognition
  • global brain ischemia
  • phosphodiesterase 2 inhibitor
  • TRANSIENT FOREBRAIN ISCHEMIA
  • ELEMENT-BINDING PROTEIN
  • CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES
  • CEREBRAL-BLOOD-FLOW
  • ELEVATED PLUS-MAZE
  • LONG-TERM-MEMORY
  • NITRIC-OXIDE
  • NEUROTROPHIC FACTOR
  • ALZHEIMERS-DISEASE
  • ANXIOLYTIC-LIKE

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