@article{c4d41bb44c45486ca483a6a5ca50f03e,
title = "The Personalized Parkinson Project: examining disease progression through broad biomarkers in early Parkinson's disease",
abstract = "Background: Our understanding of the etiology, pathophysiology, phenotypic diversity, and progression of Parkinson's disease has stagnated. Consequently, patients do not receive the best care, leading to unnecessary disability, and to mounting costs for society. The Personalized Parkinson Project (PPP) proposes an unbiased approach to biomarker development with multiple biomarkers measured longitudinally. Our main aims are: (a) to perform a set of hypothesis-driven analyses on the comprehensive dataset, correlating established and novel biomarkers to the rate of disease progression and to treatment response; and (b) to create a widely accessible dataset for discovery of novel biomarkers and new targets for therapeutic interventions in Parkinson's disease.Methods/design: This is a prospective, longitudinal, single-center cohort study. The cohort will comprise 650 persons with Parkinson's disease. The inclusion criteria are purposely broad: age >= 18 years; and disease durationDiscussion: The PPP has several distinguishing elements: all assessments are done in a single center; inclusion of {"}real life{"} subjects; deep and repeated multi-dimensional phenotyping; and continuous monitoring with a wearable device for 2 years. Also, the PPP is powered by privacy and security by design, allowing for data sharing with scientists worldwide respecting participants' privacy. The data are expected to open the way for important new insights, including identification of biomarkers to predict differences in prognosis and treatment response between patients. Our long-term aim is to improve existing treatments, develop new therapeutic approaches, and offer Parkinson's disease patients a more personalized disease management approach.",
keywords = "Cohort studies, Parkinson's disease, Biomarkers, Disease progression, Wearable device, MILD COGNITIVE IMPAIRMENT, VALIDITY, QUESTIONNAIRE, RELIABILITY, SLEEPINESS, SUBTYPES, SCALES, CARE",
author = "Bloem, {B. R.} and Marks, {W. J.} and {Silva de Lima}, {A. L.} and Kuijf, {M. L.} and {van Laar}, T. and Jacobs, {B. P. F.} and Verbeek, {M. M.} and Helmich, {R. C.} and {van de Warrenburg}, {B. P.} and Evers, {L. J. W.} and J. IntHout and {van de Zande}, T. and Snyder, {T. M.} and R. Kapur and Meinders, {M. J.}",
note = "Funding Information: BRB, ALSdL, MLK, TvL, BPFJ, MMV, RCH, BPvdW, LJWE, JiH, TvdZ and MJM declare to have no competing interest. WJM, TMS and RK are employees of, and equity holder in, Verily Life Sciences LLC. For the sake of transparency, a full list of disclosures of the first author, Bastiaan R Bloem, is provided: BR Bloem currently serves as Associate Editor for the Journal of Parkinson{\textquoteright}s disease, has received honoraria from serving on the scientific advisory board for Zambon and Kyowa Kirin, has received fees for speaking at conferences from AbbVie, Zambon and Bial, and has received research support from the Netherlands Organization for Scientific Research (NWO), the Michael J Fox Foundation for Parkinson{\textquoteright}s Research, UCB, the Stichting Parkinson Fonds, the Hersenstichting Nederland, the Parkinson{\textquoteright}s Foundation, Verily Life Sciences, Topsector Life Sciences and Health, and the Parkinson Vereniging. Funding Information: The study is financially supported by Verily Life Sciences LLC, Radboud university medical center, Radboud University, the city of Nijmegen and the Province of Gelderland. The collaboration project is co-funded by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships. The co-authors employed by Verily Life Sciences LCC (BRB, RK and TMS) were involved in the design of the study and preparation of the manuscript. The other study sponsors had no role in study design and collection, analysis and interpretation of data or in writing the manuscript. Publisher Copyright: {\textcopyright} 2019 The Author(s).",
year = "2019",
month = jul,
day = "17",
doi = "10.1186/s12883-019-1394-3",
language = "English",
volume = "19",
journal = "BMC Neurology",
issn = "1471-2377",
publisher = "BioMed Central Ltd",
number = "1",
}