TY - JOUR
T1 - The neonatal window of opportunity-early priming for life
AU - Renz, Harald
AU - Adkins, Becky D.
AU - Bartfeld, Sina
AU - Blumberg, Richard S.
AU - Farber, Donna L.
AU - Garssen, Johan
AU - Ghazal, Peter
AU - Hackam, David J.
AU - Marsland, Benjamin J.
AU - McCoy, Kathy D.
AU - Penders, John
AU - Prinz, Immo
AU - Verhasselt, Valerie
AU - von Mutius, Erika
AU - Weiser, Jeffrey N.
AU - Wesemann, Duane R.
AU - Hornef, Mathias W.
PY - 2018/4
Y1 - 2018/4
N2 - The concept of the neonatal window of opportunity assigns the early postnatal period a critical role for lifelong host-microbial and immune homeostasis. It is supported by epidemiological evidence that links postnatal environmental exposure with disease susceptibility and mechanisms in the neonate host that facilitate the postnatal transposition, establish a stable microbiome, and promote immune maturation. During the conference on “The neonatal window of opportunity – early priming for life,” postnatal micro-biome and immune maturation, epidemiological evidence, and fundamental mechanisms were discussed to identify new targets for future preventive and interventional measures. From December 5 to 7, 2016, the Herrenhausen Conference “The neonatal window of opportunity – early priming for life” took place at Hannover, Germany, sponsored by the Volkswagen Foundation. The concept of the “neonatal window of opportunity,” that is, a critical nonredundant time frame in a newborn’s life during which environmental factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life, was discussed.
AB - The concept of the neonatal window of opportunity assigns the early postnatal period a critical role for lifelong host-microbial and immune homeostasis. It is supported by epidemiological evidence that links postnatal environmental exposure with disease susceptibility and mechanisms in the neonate host that facilitate the postnatal transposition, establish a stable microbiome, and promote immune maturation. During the conference on “The neonatal window of opportunity – early priming for life,” postnatal micro-biome and immune maturation, epidemiological evidence, and fundamental mechanisms were discussed to identify new targets for future preventive and interventional measures. From December 5 to 7, 2016, the Herrenhausen Conference “The neonatal window of opportunity – early priming for life” took place at Hannover, Germany, sponsored by the Volkswagen Foundation. The concept of the “neonatal window of opportunity,” that is, a critical nonredundant time frame in a newborn’s life during which environmental factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult life, was discussed.
KW - MICROBIOTA
U2 - 10.1016/j.jaci.2017.11.019
DO - 10.1016/j.jaci.2017.11.019
M3 - Editorial
C2 - 29247715
SN - 0091-6749
VL - 141
SP - 1212
EP - 1214
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 4
ER -