The Muscle Oxidative Regulatory Response to Acute Exercise Is Not Impaired in Less Advanced COPD Despite a Decreased Oxidative Phenotype

I.G. Slot, B. van den Borst, V.A. Hellwig, E. Barreiro, Annemie M. W. J. Schols, Harry R. Gosker

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Already in an early disease stage, patients with chronic obstructive pulmonary disease (COPD) are confronted with impaired skeletal muscle function and physical performance due to a loss of oxidative type I muscle fibers and oxidative capacity (i.e. oxidative phenotype; Oxphen). Physical activity is a well-known stimulus of muscle Oxphen and crucial for its maintenance. We hypothesized that a blunted response of Oxphen genes to an acute bout of exercise could contribute to decreased Oxphen in COPD. For this, 28 patients with less advanced COPD (age 65 +/- 7 yrs, FEV1 59 +/- 16% predicted) and 15 age- and gender-matched healthy controls performed an incremental cycle ergometry test. The Oxphen response to exercise was determined by the measurement of gene expression levels of Oxphen markers in pre and 4h-post exercise quadriceps biopsies. Because exercise-induced hypoxia and oxidative stress may interfere with Oxphen response, oxygen saturation and oxidative stress markers were assessed as well. Regardless of oxygen desaturation and absolute exercise intensities, the Oxphen regulatory response to exercise was comparable between COPD patients and controls with no evidence of increased oxidative stress. In conclusion, the muscle Oxphen regulatory response to acute exercise is not blunted in less advanced COPD, regardless of exercise-induced hypoxia. Hence, this study provides further rationale for incorporation of exercise training as integrated part of disease management to prevent or slow down loss of muscle Oxphen and related functional impairment in COPD.
Original languageEnglish
Article numbere90150
Number of pages9
JournalPLOS ONE
Volume9
Issue number2
DOIs
Publication statusPublished - 28 Feb 2014

Keywords

  • OBSTRUCTIVE PULMONARY-DISEASE
  • HUMAN SKELETAL-MUSCLE
  • MESSENGER-RNA EXPRESSION
  • VASTUS LATERALIS MUSCLE
  • PERIPHERAL MUSCLE
  • GENE-EXPRESSION
  • HYPOBARIC HYPOXIA
  • ENDURANCE
  • STRESS
  • DYSFUNCTION

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