The MOPEAD project: Advancing patient engagement for the detection of "hidden" undiagnosed cases of Alzheimer's disease in the community

Octavio Rodriguez-Gomez*, Adrian Rodrigo, Fatima Iradier, Miguel A. Santos-Santos, Hans Hundemer, Andreea Ciudin, Lena Sannemann, Marissa Zwan, Bridget Glaysher, Anders Wimo, Jaka Bonn, Gunilla Johansson, Isabel Rodriguez, Montse Alegret, Dianne Gove, Susana Pino, Paloma Trigueros, Miia Kivipelto, Brandy Mathews, Antonio CiudadDaniel Ferreira, Christophe Bintener, Miren Gurruchaga, Eric Westman, Mark Belger, Sergi Valero, Peggy Maguire, David Krivec, Milica Kramberger, Rafael Simo, Inmaculada Perez Garro, Pieter Jelle Visser, Annette Dumas, Jean Georges, Frank Jessen, Bengt Winblad, Craig Shering, Neil Stewart, Laura Campo, Merece Boada, MOPEAD Consortium

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review


In most, if not all health systems, dementia is underdiagnosed, and when diagnosis occurs, it is typically at a relatively late stage in the disease process despite mounting evidence showing that a timely diagnosis would result in numerous benefits for patients, families, and society. Moving toward earlier diagnoses in Alzheimer's disease (AD) requires a conscientious and collective effort to implement a global strategy addressing the multiple causes hindering patient engagement at different levels of society. This article describes the design of the Models of Patient Engagement for Alzheimer's Disease project, an ongoing EU-funded public-private multinational initiative that will compare four innovative patient engagement strategies across five European countries regarding their ability to identify individuals with prodromal AD and mild AD dementia, which are "hidden" in their communities and traditionally not found in the typical memory clinic setting. The strategies include an online AD citizen science platform, an open house initiative at the memory clinics, and patient engagement at primary care and diabetologist clinics. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY-NC-ND license (

Original languageEnglish
Pages (from-to)828-839
Number of pages12
JournalAlzheimer's & Dementia
Issue number6
Publication statusPublished - Jun 2019


  • Alzheimer's disease
  • Early diagnosis
  • Diagnostic gap
  • Patient engagement
  • Population-based screening
  • Citizen science
  • CARE

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