The mechanism of action of oral anticoagulants and its consequenses for the practice of oral anticoagulation

H.C. Hemker; H.L.L. Frank

doi:10.1159/000215158

The mechanism of action of oral anticoagulants and its consequenses for the practice of oral anticoagulation

H.C. Hemker, H.L.L. Frank

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Abstract

A short review on the discovery of the relation between vitamin K and the synthesis of clotting factors and on the development of anticoagulant therapy is given. The pro-coagulant activity induced by vitamin K resides in the postribosomal modification of N-terminal glutamic acids in γ-COOH glutamic acids. The mode of action of oral anticoagulants is explained. The concentration-effect relations and the choice of an oral anticoagulant is discussed.

Original language	English
Pages (from-to)	263-270
Number of pages	8
Journal	Haemostasis
Volume	15
Issue number	4
DOIs	https://doi.org/10.1159/000215158
Publication status	Published - 1985

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title = "The mechanism of action of oral anticoagulants and its consequenses for the practice of oral anticoagulation",

abstract = "A short review on the discovery of the relation between vitamin K and the synthesis of clotting factors and on the development of anticoagulant therapy is given. The pro-coagulant activity induced by vitamin K resides in the postribosomal modification of N-terminal glutamic acids in γ-COOH glutamic acids. The mode of action of oral anticoagulants is explained. The concentration-effect relations and the choice of an oral anticoagulant is discussed.",

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AB - A short review on the discovery of the relation between vitamin K and the synthesis of clotting factors and on the development of anticoagulant therapy is given. The pro-coagulant activity induced by vitamin K resides in the postribosomal modification of N-terminal glutamic acids in γ-COOH glutamic acids. The mode of action of oral anticoagulants is explained. The concentration-effect relations and the choice of an oral anticoagulant is discussed.

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