Abstract
A short review on the discovery of the relation between vitamin K and the synthesis of clotting factors and on the development of anticoagulant therapy is given. The pro-coagulant activity induced by vitamin K resides in the postribosomal modification of N-terminal glutamic acids in γ-COOH glutamic acids. The mode of action of oral anticoagulants is explained. The concentration-effect relations and the choice of an oral anticoagulant is discussed.
Original language | English |
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Pages (from-to) | 263-270 |
Number of pages | 8 |
Journal | Haemostasis |
Volume | 15 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1985 |