The mechanism of action of oral anticoagulants and its consequenses for the practice of oral anticoagulation

H.C. Hemker, H.L.L. Frank

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    A short review on the discovery of the relation between vitamin K and the synthesis of clotting factors and on the development of anticoagulant therapy is given. The pro-coagulant activity induced by vitamin K resides in the postribosomal modification of N-terminal glutamic acids in γ-COOH glutamic acids. The mode of action of oral anticoagulants is explained. The concentration-effect relations and the choice of an oral anticoagulant is discussed.
    Original languageEnglish
    Pages (from-to)263-270
    Number of pages8
    Issue number4
    Publication statusPublished - 1985

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