TY - JOUR
T1 - The link between cognition and somatic conditions related to insulin resistance in the UK Biobank study cohort
T2 - a systematic review
AU - Fanelli, Giuseppe
AU - Mota, Nina Roth
AU - Salas-Salvadó, Jordi
AU - Bulló, Mònica
AU - Fernandez-Aranda, Fernando
AU - Camacho-Barcia, Lucía
AU - Testa, Giulia
AU - Jiménez-Murcia, Susana
AU - Bertaina-Anglade, Valérie
AU - Franke, Barbara
AU - Poelmans, Geert
AU - van Gils, Veerle
AU - Jansen, Willemijn J
AU - Vos, Stephanie J B
AU - Wimberley, Theresa
AU - Dalsgaard, Søren
AU - Barta, Csaba
AU - Serretti, Alessandro
AU - Fabbri, Chiara
AU - Bralten, Janita
N1 - Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2022/12
Y1 - 2022/12
N2 - Clinical and genomic studies have shown an overlap between neuropsychiatric disorders and insulin resistance (IR)-related somatic conditions, including obesity, type 2 diabetes, and cardiovascular diseases. Impaired cognition is often observed among neuropsychiatric disorders, where multiple cognitive domains may be affected. In this review, we aimed to summarise previous evidence on the relationship between IR-related diseases/traits and cognitive performance in the large UK Biobank study cohort. Electronic searches were conducted on PubMed, Scopus, and Web of Science until April 2022. Eighteen articles met the inclusion criteria and were qualitatively reviewed. Overall, there is substantial evidence for an association between IR-related cardio-metabolic diseases/traits and worse performance on various cognitive domains, which is largely independent of possible confoundings. The most consistent findings referred to IR-related associations with poorer verbal and numerical reasoning ability, as well as slower processing speed. The observed associations might be mediated by alterations in immune-inflammation, brain integrity/connectivity, and/or comorbid somatic or psychiatric diseases/traits. Our findings provide impetus for further research into the underlying neurobiology and possible new therapeutic targets.
AB - Clinical and genomic studies have shown an overlap between neuropsychiatric disorders and insulin resistance (IR)-related somatic conditions, including obesity, type 2 diabetes, and cardiovascular diseases. Impaired cognition is often observed among neuropsychiatric disorders, where multiple cognitive domains may be affected. In this review, we aimed to summarise previous evidence on the relationship between IR-related diseases/traits and cognitive performance in the large UK Biobank study cohort. Electronic searches were conducted on PubMed, Scopus, and Web of Science until April 2022. Eighteen articles met the inclusion criteria and were qualitatively reviewed. Overall, there is substantial evidence for an association between IR-related cardio-metabolic diseases/traits and worse performance on various cognitive domains, which is largely independent of possible confoundings. The most consistent findings referred to IR-related associations with poorer verbal and numerical reasoning ability, as well as slower processing speed. The observed associations might be mediated by alterations in immune-inflammation, brain integrity/connectivity, and/or comorbid somatic or psychiatric diseases/traits. Our findings provide impetus for further research into the underlying neurobiology and possible new therapeutic targets.
U2 - 10.1016/j.neubiorev.2022.104927
DO - 10.1016/j.neubiorev.2022.104927
M3 - (Systematic) Review article
C2 - 36367493
SN - 0149-7634
VL - 143
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 104927
ER -