Abstract
Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.
Original language | English |
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Pages (from-to) | 197-209 |
Number of pages | 13 |
Journal | Physiology |
Volume | 32 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 2017 |
Keywords
- ROSTRAL VENTROLATERAL MEDULLA
- DIET-INDUCED OBESITY
- SMOOTH-MUSCLE-CELLS
- CONVERTING ENZYME 2
- TUBULE NA+-ATPASE
- MINERALOCORTICOID RECEPTOR ANTAGONISM
- IMPROVES ENDOTHELIAL FUNCTION
- INDUCED CAPILLARY RECRUITMENT
- SYMPATHETIC AFFERENT REFLEX
- INSULINS METABOLIC ACTION