The Link Between Adipose Tissue Renin-Angiotensin- Aldosterone System Signaling and Obesity-Associated Hypertension

Monica T. J. Schutten; Alfons J. H. M. Houben; Peter W. de Leeuw; Coen D. A. Stehouwer

doi:10.1152/physiol.00037.2016

The Link Between Adipose Tissue Renin-Angiotensin- Aldosterone System Signaling and Obesity-Associated Hypertension

Monica T. J. Schutten, Alfons J. H. M. Houben, Peter W. de Leeuw, Coen D. A. Stehouwer^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.

Original language	English
Pages (from-to)	197-209
Number of pages	13
Journal	Physiology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1152/physiol.00037.2016
Publication status	Published - May 2017

Keywords

ROSTRAL VENTROLATERAL MEDULLA
DIET-INDUCED OBESITY
SMOOTH-MUSCLE-CELLS
CONVERTING ENZYME 2
TUBULE NA+-ATPASE
MINERALOCORTICOID RECEPTOR ANTAGONISM
IMPROVES ENDOTHELIAL FUNCTION
INDUCED CAPILLARY RECRUITMENT
SYMPATHETIC AFFERENT REFLEX
INSULINS METABOLIC ACTION

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10.1152/physiol.00037.2016

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Cite this

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title = "The Link Between Adipose Tissue Renin-Angiotensin- Aldosterone System Signaling and Obesity-Associated Hypertension",

abstract = "Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.",

keywords = "ROSTRAL VENTROLATERAL MEDULLA, DIET-INDUCED OBESITY, SMOOTH-MUSCLE-CELLS, CONVERTING ENZYME 2, TUBULE NA+-ATPASE, MINERALOCORTICOID RECEPTOR ANTAGONISM, IMPROVES ENDOTHELIAL FUNCTION, INDUCED CAPILLARY RECRUITMENT, SYMPATHETIC AFFERENT REFLEX, INSULINS METABOLIC ACTION",

author = "Schutten, {Monica T. J.} and Houben, {Alfons J. H. M.} and {de Leeuw}, {Peter W.} and Stehouwer, {Coen D. A.}",

year = "2017",

month = may,

doi = "10.1152/physiol.00037.2016",

language = "English",

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journal = "Physiology",

issn = "1548-9213",

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AU - Schutten, Monica T. J.

AU - Houben, Alfons J. H. M.

AU - de Leeuw, Peter W.

AU - Stehouwer, Coen D. A.

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AB - Obese individuals frequently develop hypertension, which is for an important part attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review summarizes preclinical and clinical evidence on the involvement of dysfunctional adipose tissue in RAAS activation and on the renal, central, and vascular mechanisms linking RAAS components to obesity-associated hypertension.

KW - ROSTRAL VENTROLATERAL MEDULLA

KW - DIET-INDUCED OBESITY

KW - SMOOTH-MUSCLE-CELLS

KW - CONVERTING ENZYME 2

KW - TUBULE NA+-ATPASE

KW - MINERALOCORTICOID RECEPTOR ANTAGONISM

KW - IMPROVES ENDOTHELIAL FUNCTION

KW - INDUCED CAPILLARY RECRUITMENT

KW - SYMPATHETIC AFFERENT REFLEX

KW - INSULINS METABOLIC ACTION

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DO - 10.1152/physiol.00037.2016

M3 - (Systematic) Review article

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