TY - JOUR
T1 - The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry
AU - Hughes, Stella E
AU - Spelman, Timothy
AU - Trojano, Maria
AU - Lugaresi, Alessandra
AU - Izquierdo, Guillermo
AU - Grand'Maison, Francois
AU - Duquette, Pierre
AU - Girard, Marc
AU - Grammond, Pierre
AU - Oreja-Guevara, Celia
AU - Hupperts, Raymond
AU - Boz, Cavit
AU - Bergamaschi, Roberto
AU - Giuliani, Giorgio
AU - Rio, Maria Edite
AU - Lechner-Scott, Jeannette
AU - Van Pesch, Vincent
AU - Iuliano, Gerardo
AU - Fiol, Marcela
AU - Verheul, Freek
AU - Barnett, Michael
AU - Slee, Mark
AU - Herbert, Joseph
AU - Kister, Ilya
AU - Vella, Norbert
AU - Moore, Fraser
AU - Petkovska-Boskova, Tatjana
AU - Shaygannejad, Vahid
AU - Jokubaitis, Vilija
AU - McDonnell, Gavin
AU - Hawkins, Stanley
AU - Kee, Frank
AU - Gray, Orla
AU - Butzkueven, Helmut
PY - 2012/3
Y1 - 2012/3
N2 - The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry.Rank stability of EDSS over time was examined in the MSBase Registry, a large multicentre MS cohort. Scores were ranked for 5-year intervals, and correlation of rank across intervals was assessed using Spearman's rank correlation. EDSS progression outcomes at 10 years were disaggregated by 5-year EDSS scores.Correlation coefficients for EDSS rank over 5-year intervals increased with MS duration: years 1-6=0.55, years 4-9=0.74, years 7-12=0.80 and years 10-15=0.83. EDSS progression risk at 10 years after onset was highly dependent on EDSS at 5 years; one-point progression risk was greater for EDSS score of >2 than ?2. Two-point progression was uncommon for EDSS score of
AB - The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry.Rank stability of EDSS over time was examined in the MSBase Registry, a large multicentre MS cohort. Scores were ranked for 5-year intervals, and correlation of rank across intervals was assessed using Spearman's rank correlation. EDSS progression outcomes at 10 years were disaggregated by 5-year EDSS scores.Correlation coefficients for EDSS rank over 5-year intervals increased with MS duration: years 1-6=0.55, years 4-9=0.74, years 7-12=0.80 and years 10-15=0.83. EDSS progression risk at 10 years after onset was highly dependent on EDSS at 5 years; one-point progression risk was greater for EDSS score of >2 than ?2. Two-point progression was uncommon for EDSS score of
U2 - 10.1136/jnnp-2011-301051
DO - 10.1136/jnnp-2011-301051
M3 - Article
C2 - 22205675
SN - 0022-3050
VL - 83
SP - 305
EP - 310
JO - Journal of Neurology Neurosurgery and Psychiatry
JF - Journal of Neurology Neurosurgery and Psychiatry
IS - 3
ER -