The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry

Stella E Hughes, Timothy Spelman, Maria Trojano, Alessandra Lugaresi, Guillermo Izquierdo, Francois Grand'Maison, Pierre Duquette, Marc Girard, Pierre Grammond, Celia Oreja-Guevara, Raymond Hupperts, Cavit Boz, Roberto Bergamaschi, Giorgio Giuliani, Maria Edite Rio, Jeannette Lechner-Scott, Vincent Van Pesch, Gerardo Iuliano, Marcela Fiol, Freek VerheulMichael Barnett, Mark Slee, Joseph Herbert, Ilya Kister, Norbert Vella, Fraser Moore, Tatjana Petkovska-Boskova, Vahid Shaygannejad, Vilija Jokubaitis, Gavin McDonnell, Stanley Hawkins, Frank Kee, Orla Gray, Helmut Butzkueven*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry.Rank stability of EDSS over time was examined in the MSBase Registry, a large multicentre MS cohort. Scores were ranked for 5-year intervals, and correlation of rank across intervals was assessed using Spearman's rank correlation. EDSS progression outcomes at 10 years were disaggregated by 5-year EDSS scores.Correlation coefficients for EDSS rank over 5-year intervals increased with MS duration: years 1-6=0.55, years 4-9=0.74, years 7-12=0.80 and years 10-15=0.83. EDSS progression risk at 10 years after onset was highly dependent on EDSS at 5 years; one-point progression risk was greater for EDSS score of >2 than ?2. Two-point progression was uncommon for EDSS score of
Original languageEnglish
Pages (from-to)305-310
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number3
Publication statusPublished - Mar 2012

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