The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

Yuan Ji, Rosanne Varkevisser, Dragan Opacic, Alexandre Bossu, Marion Kuiper, Jet D. M. Beekman, Sihyung Yang, Azinwi Phina Khan, Dobromir Dobrev, Niels Voigt, Michael Zhuo Wang, Sander Verheule, Marc A. Vos, Marcel A. G. van der Heyden*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2576-2590
Number of pages15
JournalBritish Journal of Pharmacology
Volume174
Issue number15
DOIs
Publication statusPublished - Aug 2017

Keywords

  • HUMAN AFRICAN TRYPANOSOMIASIS
  • TORSADES-DE-POINTES
  • POTASSIUM CURRENT
  • CARDIAC REPOLARIZATION
  • ATRIOVENTRICULAR-BLOCK
  • TRANSMURAL CONDUCTION
  • IONIC MECHANISMS
  • UP-REGULATION
  • CURRENT I-K1
  • III DRUGS

Cite this

Ji, Y., Varkevisser, R., Opacic, D., Bossu, A., Kuiper, M., Beekman, J. D. M., Yang, S., Khan, A. P., Dobrev, D., Voigt, N., Wang, M. Z., Verheule, S., Vos, M. A., & van der Heyden, M. A. G. (2017). The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. British Journal of Pharmacology, 174(15), 2576-2590. https://doi.org/10.1111/bph.13869