The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

Yuan Ji, Rosanne Varkevisser, Dragan Opacic, Alexandre Bossu, Marion Kuiper, Jet D. M. Beekman, Sihyung Yang, Azinwi Phina Khan, Dobromir Dobrev, Niels Voigt, Michael Zhuo Wang, Sander Verheule, Marc A. Vos, Marcel A. G. van der Heyden*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2576-2590
Number of pages15
JournalBritish Journal of Pharmacology
Volume174
Issue number15
DOIs
Publication statusPublished - Aug 2017

Keywords

  • HUMAN AFRICAN TRYPANOSOMIASIS
  • TORSADES-DE-POINTES
  • POTASSIUM CURRENT
  • CARDIAC REPOLARIZATION
  • ATRIOVENTRICULAR-BLOCK
  • TRANSMURAL CONDUCTION
  • IONIC MECHANISMS
  • UP-REGULATION
  • CURRENT I-K1
  • III DRUGS

Cite this

Ji, Y., Varkevisser, R., Opacic, D., Bossu, A., Kuiper, M., Beekman, J. D. M., ... van der Heyden, M. A. G. (2017). The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. British Journal of Pharmacology, 174(15), 2576-2590. https://doi.org/10.1111/bph.13869
Ji, Yuan ; Varkevisser, Rosanne ; Opacic, Dragan ; Bossu, Alexandre ; Kuiper, Marion ; Beekman, Jet D. M. ; Yang, Sihyung ; Khan, Azinwi Phina ; Dobrev, Dobromir ; Voigt, Niels ; Wang, Michael Zhuo ; Verheule, Sander ; Vos, Marc A. ; van der Heyden, Marcel A. G. / The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. In: British Journal of Pharmacology. 2017 ; Vol. 174, No. 15. pp. 2576-2590.
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title = "The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models",
keywords = "HUMAN AFRICAN TRYPANOSOMIASIS, TORSADES-DE-POINTES, POTASSIUM CURRENT, CARDIAC REPOLARIZATION, ATRIOVENTRICULAR-BLOCK, TRANSMURAL CONDUCTION, IONIC MECHANISMS, UP-REGULATION, CURRENT I-K1, III DRUGS",
author = "Yuan Ji and Rosanne Varkevisser and Dragan Opacic and Alexandre Bossu and Marion Kuiper and Beekman, {Jet D. M.} and Sihyung Yang and Khan, {Azinwi Phina} and Dobromir Dobrev and Niels Voigt and Wang, {Michael Zhuo} and Sander Verheule and Vos, {Marc A.} and {van der Heyden}, {Marcel A. G.}",
year = "2017",
month = "8",
doi = "10.1111/bph.13869",
language = "English",
volume = "174",
pages = "2576--2590",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "15",

}

Ji, Y, Varkevisser, R, Opacic, D, Bossu, A, Kuiper, M, Beekman, JDM, Yang, S, Khan, AP, Dobrev, D, Voigt, N, Wang, MZ, Verheule, S, Vos, MA & van der Heyden, MAG 2017, 'The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models', British Journal of Pharmacology, vol. 174, no. 15, pp. 2576-2590. https://doi.org/10.1111/bph.13869

The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. / Ji, Yuan; Varkevisser, Rosanne; Opacic, Dragan; Bossu, Alexandre; Kuiper, Marion; Beekman, Jet D. M.; Yang, Sihyung; Khan, Azinwi Phina; Dobrev, Dobromir; Voigt, Niels; Wang, Michael Zhuo; Verheule, Sander; Vos, Marc A.; van der Heyden, Marcel A. G.

In: British Journal of Pharmacology, Vol. 174, No. 15, 08.2017, p. 2576-2590.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

AU - Ji, Yuan

AU - Varkevisser, Rosanne

AU - Opacic, Dragan

AU - Bossu, Alexandre

AU - Kuiper, Marion

AU - Beekman, Jet D. M.

AU - Yang, Sihyung

AU - Khan, Azinwi Phina

AU - Dobrev, Dobromir

AU - Voigt, Niels

AU - Wang, Michael Zhuo

AU - Verheule, Sander

AU - Vos, Marc A.

AU - van der Heyden, Marcel A. G.

PY - 2017/8

Y1 - 2017/8

KW - HUMAN AFRICAN TRYPANOSOMIASIS

KW - TORSADES-DE-POINTES

KW - POTASSIUM CURRENT

KW - CARDIAC REPOLARIZATION

KW - ATRIOVENTRICULAR-BLOCK

KW - TRANSMURAL CONDUCTION

KW - IONIC MECHANISMS

KW - UP-REGULATION

KW - CURRENT I-K1

KW - III DRUGS

U2 - 10.1111/bph.13869

DO - 10.1111/bph.13869

M3 - Article

VL - 174

SP - 2576

EP - 2590

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 15

ER -