The interplay between neuroinflammatory pathways and Parkinson's disease

Pinar Eser; Ersoy Kocabicak; Ahmet Bekar; Yasin Temel

doi:10.1016/j.expneurol.2023.114644

The interplay between neuroinflammatory pathways and Parkinson's disease

Pinar Eser^*
, Ersoy Kocabicak
, Ahmet Bekar
, Yasin Temel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Parkinson's disease, a progressive neurodegenerative disorder predominantly affecting elderly, is marked by the gradual degeneration of the nigrostriatal dopaminergic pathway, culminating in neuronal loss within the substantia nigra pars compacta (SNpc) and dopamine depletion. At the molecular level, neuronal loss in the SNpc has been attributed to factors including neuroinflammation, impaired protein homeostasis, as well as mitochondrial dysfunction and the resulting oxidative stress. This review focuses on the interplay between neuroinflammatory pathways and Parkinson's disease, drawing insights from current literature.

Original language	English
Article number	114644
Number of pages	11
Journal	Experimental Neurology
Volume	372
Early online date	5 Dec 2023
DOIs	https://doi.org/10.1016/j.expneurol.2023.114644
Publication status	Published - Feb 2024

Keywords

Mitochondria dysfunction
Neuroinflammation
Parkinson's disease

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10.1016/j.expneurol.2023.114644

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AB - Parkinson's disease, a progressive neurodegenerative disorder predominantly affecting elderly, is marked by the gradual degeneration of the nigrostriatal dopaminergic pathway, culminating in neuronal loss within the substantia nigra pars compacta (SNpc) and dopamine depletion. At the molecular level, neuronal loss in the SNpc has been attributed to factors including neuroinflammation, impaired protein homeostasis, as well as mitochondrial dysfunction and the resulting oxidative stress. This review focuses on the interplay between neuroinflammatory pathways and Parkinson's disease, drawing insights from current literature.

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The interplay between neuroinflammatory pathways and Parkinson's disease

Abstract

Keywords

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