The inhibition of platelet prothrombinase activity by prostacyclin

R.F.A. Zwaal, P. Comfurius, H.C. Hemker, E.M. Beves

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    Abstract

    Prostacyclin is able to inhibit the development of platelet prothrombinase activity. This inhibition, which also occurs with dibutyryl cAMP, is presumably due to the ability of prostacyclin to prevent the formation of a negatively charged phospholipid surface at the exterior half of the platelet membrane. Generation of this procoagulant surface, as induced by platelet activation with collagen plus thrombin, does not depend on thromboxane A2 formation.
    Original languageEnglish
    Pages (from-to)320-324
    Number of pages5
    JournalHaemostasis
    Volume14
    Issue number4
    DOIs
    Publication statusPublished - 1984

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