The influence of the polyene filipin on the extrinsic pathway of blood coagulation

P.M. van der Plas; G. van Es; L. Kraan; H.C. Hemker

doi:10.1159/000213985

The influence of the polyene filipin on the extrinsic pathway of blood coagulation

P.M. van der Plas
, G. van Es
, L. Kraan
, H.C. Hemker

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The inhibition by filipin in the extrinsic blood clotting system takes place at two sites: (1) at the interaction of factor VII, tissue thromboplastin and Ca++, and (2) at the prothrombinase level. Both formation and enzymatic activity of the prothrombinase are inhibited.The cholesterol content of the lipid that is used to form the prothrombinase complex determines the degree of inhibition by filipin. The inhibition increases the higher the sterol content. The adsorption of factors Xa and V onto lipid surface is enhanced by filipin. This increased adsorption does not lead to an increase in prothrombinase production.

Original language	English
Pages (from-to)	191-203
Number of pages	13
Journal	Haemostasis
Volume	1972-1973
Issue number	1
DOIs	https://doi.org/10.1159/000213985
Publication status	Published - 1972
Externally published	Yes

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title = "The influence of the polyene filipin on the extrinsic pathway of blood coagulation",

abstract = "The inhibition by filipin in the extrinsic blood clotting system takes place at two sites: (1) at the interaction of factor VII, tissue thromboplastin and Ca++, and (2) at the prothrombinase level. Both formation and enzymatic activity of the prothrombinase are inhibited.The cholesterol content of the lipid that is used to form the prothrombinase complex determines the degree of inhibition by filipin. The inhibition increases the higher the sterol content. The adsorption of factors Xa and V onto lipid surface is enhanced by filipin. This increased adsorption does not lead to an increase in prothrombinase production.",

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AU - Kraan, L.

AU - Hemker, H.C.

PY - 1972

Y1 - 1972

N2 - The inhibition by filipin in the extrinsic blood clotting system takes place at two sites: (1) at the interaction of factor VII, tissue thromboplastin and Ca++, and (2) at the prothrombinase level. Both formation and enzymatic activity of the prothrombinase are inhibited.The cholesterol content of the lipid that is used to form the prothrombinase complex determines the degree of inhibition by filipin. The inhibition increases the higher the sterol content. The adsorption of factors Xa and V onto lipid surface is enhanced by filipin. This increased adsorption does not lead to an increase in prothrombinase production.

AB - The inhibition by filipin in the extrinsic blood clotting system takes place at two sites: (1) at the interaction of factor VII, tissue thromboplastin and Ca++, and (2) at the prothrombinase level. Both formation and enzymatic activity of the prothrombinase are inhibited.The cholesterol content of the lipid that is used to form the prothrombinase complex determines the degree of inhibition by filipin. The inhibition increases the higher the sterol content. The adsorption of factors Xa and V onto lipid surface is enhanced by filipin. This increased adsorption does not lead to an increase in prothrombinase production.

U2 - 10.1159/000213985

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JO - Haemostasis

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ER -

The influence of the polyene filipin on the extrinsic pathway of blood coagulation

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