The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age

Arian W Plat; Henri E Stoffers; Peter W de Leeuw; Constant P van Schayck; Frank L Soomers; Arnold D Kester; Karin Aretz; Abraham A Kroon

doi:10.1097/MCA.0b013e328330d541

The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age

Arian W Plat
, Henri E Stoffers
, Peter W de Leeuw
, Constant P van Schayck
, Frank L Soomers
, Arnold D Kester
, Karin Aretz
, Abraham A Kroon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age.

METHODS: In this cross sectional case-control study, patients with a first event of IHD (157) and event-free controls (571) were studied. Both the groups were genotyped for the angiotensin II type 1 receptor (A1166C), angiotensinogen (M235 T), angiotensin converting enzyme (4656rpt), endothelial nitric oxide synthase (E298D), G-protein beta3 subunit (C825 T), and alpha-adducin (G460W) polymorphisms. Univariate and multivariate odds ratios (ORs) were calculated to assess the association between a first ischemic event and these polymorphisms. Sliding mean analyses were performed to show age-specific associations.

RESULTS: Multivariate ORs indicated a protective association for the carrier status of the T-allele of AGT, overall [OR = 0.69 (0.34-0.90)] and for males [OR = 0.58 (0.27-0.89)]. Sliding mean analyses showed a continuous protective association with IHD of the T-allele of AGT with increasing age in males, whereas in females an increased risk for IHD was observed with a maximum OR of 1.6 at the age of 56 years.

CONCLUSION: In this population the T-allele of the AGT polymorphism is protective for a first event of IHD in males.

Original language	English
Pages (from-to)	499-505
Number of pages	7
Journal	Coronary Artery Disease
Volume	20
Issue number	8
DOIs	https://doi.org/10.1097/MCA.0b013e328330d541
Publication status	Published - Dec 2009

Keywords

Age Factors
Aged
Angiotensinogen/genetics
Calmodulin-Binding Proteins/genetics
Case-Control Studies
Cross-Sectional Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Heterotrimeric GTP-Binding Proteins/genetics
Humans
Hypertension/complications
Logistic Models
Male
Middle Aged
Myocardial Ischemia/genetics
Nitric Oxide Synthase Type III/genetics
Odds Ratio
Peptidyl-Dipeptidase A/genetics
Polymorphism, Genetic
Primary Health Care
Receptor, Angiotensin, Type 1/genetics
Risk Assessment
Risk Factors
Sex Factors

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10.1097/MCA.0b013e328330d541

Cite this

@article{f9918f8db6ea40d293b67ffd232ce4e2,

title = "The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age",

abstract = "OBJECTIVE: To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age.METHODS: In this cross sectional case-control study, patients with a first event of IHD (157) and event-free controls (571) were studied. Both the groups were genotyped for the angiotensin II type 1 receptor (A1166C), angiotensinogen (M235 T), angiotensin converting enzyme (4656rpt), endothelial nitric oxide synthase (E298D), G-protein beta3 subunit (C825 T), and alpha-adducin (G460W) polymorphisms. Univariate and multivariate odds ratios (ORs) were calculated to assess the association between a first ischemic event and these polymorphisms. Sliding mean analyses were performed to show age-specific associations.RESULTS: Multivariate ORs indicated a protective association for the carrier status of the T-allele of AGT, overall [OR = 0.69 (0.34-0.90)] and for males [OR = 0.58 (0.27-0.89)]. Sliding mean analyses showed a continuous protective association with IHD of the T-allele of AGT with increasing age in males, whereas in females an increased risk for IHD was observed with a maximum OR of 1.6 at the age of 56 years.CONCLUSION: In this population the T-allele of the AGT polymorphism is protective for a first event of IHD in males.",

keywords = "Age Factors, Aged, Angiotensinogen/genetics, Calmodulin-Binding Proteins/genetics, Case-Control Studies, Cross-Sectional Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Heterotrimeric GTP-Binding Proteins/genetics, Humans, Hypertension/complications, Logistic Models, Male, Middle Aged, Myocardial Ischemia/genetics, Nitric Oxide Synthase Type III/genetics, Odds Ratio, Peptidyl-Dipeptidase A/genetics, Polymorphism, Genetic, Primary Health Care, Receptor, Angiotensin, Type 1/genetics, Risk Assessment, Risk Factors, Sex Factors",

author = "Plat, \{Arian W\} and Stoffers, \{Henri E\} and \{de Leeuw\}, \{Peter W\} and \{van Schayck\}, \{Constant P\} and Soomers, \{Frank L\} and Kester, \{Arnold D\} and Karin Aretz and Kroon, \{Abraham A\}",

year = "2009",

month = dec,

doi = "10.1097/MCA.0b013e328330d541",

language = "English",

volume = "20",

pages = "499--505",

journal = "Coronary Artery Disease",

issn = "0954-6928",

publisher = "Lippincott Williams \& Wilkins",

number = "8",

}

TY - JOUR

T1 - The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age

AU - Plat, Arian W

AU - Stoffers, Henri E

AU - de Leeuw, Peter W

AU - van Schayck, Constant P

AU - Soomers, Frank L

AU - Kester, Arnold D

AU - Aretz, Karin

AU - Kroon, Abraham A

PY - 2009/12

Y1 - 2009/12

N2 - OBJECTIVE: To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age.METHODS: In this cross sectional case-control study, patients with a first event of IHD (157) and event-free controls (571) were studied. Both the groups were genotyped for the angiotensin II type 1 receptor (A1166C), angiotensinogen (M235 T), angiotensin converting enzyme (4656rpt), endothelial nitric oxide synthase (E298D), G-protein beta3 subunit (C825 T), and alpha-adducin (G460W) polymorphisms. Univariate and multivariate odds ratios (ORs) were calculated to assess the association between a first ischemic event and these polymorphisms. Sliding mean analyses were performed to show age-specific associations.RESULTS: Multivariate ORs indicated a protective association for the carrier status of the T-allele of AGT, overall [OR = 0.69 (0.34-0.90)] and for males [OR = 0.58 (0.27-0.89)]. Sliding mean analyses showed a continuous protective association with IHD of the T-allele of AGT with increasing age in males, whereas in females an increased risk for IHD was observed with a maximum OR of 1.6 at the age of 56 years.CONCLUSION: In this population the T-allele of the AGT polymorphism is protective for a first event of IHD in males.

AB - OBJECTIVE: To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age.METHODS: In this cross sectional case-control study, patients with a first event of IHD (157) and event-free controls (571) were studied. Both the groups were genotyped for the angiotensin II type 1 receptor (A1166C), angiotensinogen (M235 T), angiotensin converting enzyme (4656rpt), endothelial nitric oxide synthase (E298D), G-protein beta3 subunit (C825 T), and alpha-adducin (G460W) polymorphisms. Univariate and multivariate odds ratios (ORs) were calculated to assess the association between a first ischemic event and these polymorphisms. Sliding mean analyses were performed to show age-specific associations.RESULTS: Multivariate ORs indicated a protective association for the carrier status of the T-allele of AGT, overall [OR = 0.69 (0.34-0.90)] and for males [OR = 0.58 (0.27-0.89)]. Sliding mean analyses showed a continuous protective association with IHD of the T-allele of AGT with increasing age in males, whereas in females an increased risk for IHD was observed with a maximum OR of 1.6 at the age of 56 years.CONCLUSION: In this population the T-allele of the AGT polymorphism is protective for a first event of IHD in males.

KW - Age Factors

KW - Aged

KW - Angiotensinogen/genetics

KW - Calmodulin-Binding Proteins/genetics

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Heterotrimeric GTP-Binding Proteins/genetics

KW - Humans

KW - Hypertension/complications

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Myocardial Ischemia/genetics

KW - Nitric Oxide Synthase Type III/genetics

KW - Odds Ratio

KW - Peptidyl-Dipeptidase A/genetics

KW - Polymorphism, Genetic

KW - Primary Health Care

KW - Receptor, Angiotensin, Type 1/genetics

KW - Risk Assessment

KW - Risk Factors

KW - Sex Factors

U2 - 10.1097/MCA.0b013e328330d541

DO - 10.1097/MCA.0b013e328330d541

M3 - Article

C2 - 19779330

SN - 0954-6928

VL - 20

SP - 499

EP - 505

JO - Coronary Artery Disease

JF - Coronary Artery Disease

IS - 8

ER -

The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age

Abstract

Keywords

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