The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata, Mary F. Feitosa, Su Chu, Jacek Czajkowski, Tonu Esko, Tove Fall, Tuomas O. Kilpelainen, Yingchang Lu, Reedik Magi, Evelin Mihailov, Tune H. Pers, Sina Rueeger, Alexander Teumer, Georg B. Ehret, Teresa Ferreira, Nancy L. Heard-Costa, Juha KarjalainenVasiliki Lagou, Anubha Mahajan, Michael D. Neinast, Inga Prokopenko, Jeannette Simino, Tanya M. Teslovich, Rick Jansen, Harm-Jan Westra, Charles C. White, Devin Absher, Tarunveer S. Ahluwalia, Shafqat Ahmad, Eva Albrecht, Alexessander Couto Alves, Jennifer L. Bragg-Gresham, Anton J. M. de Craen, Joshua C. Bis, Amelie Bonnefond, Gabrielle Boucher, Gemma Cadby, Yu-Ching Cheng, Charleston W. K. Chiang, Graciela Delgado, Ayse Demirkan, Nicole Dueker, Niina Eklund, Gudny Eiriksdottir, Joel Eriksson, Bjarke Feenstra, Krista Fischer, Francesca Frau, Tessel E. Galesloot, Frank Geller, Anuj Goel, Mathias Gorski, Tanja B. Grammer, Stefan Gustafsson, Saskia Haitjema, Jouke-Jan Hottenga, Jennifer E. Huffman, Anne U. Jackson, Kevin B. Jacobs, Asa Johansson, Marika Kaakinen, Marcus E. Kleber, Jari Lahti, Irene Mateo Leach, Benjamin Lehne, Youfang Liu, Ken Sin Lo, Mattias Lorentzon, Jian'an Luan, Pamela A. F. Madden, Massimo Mangino, Barbara McKnight, Carolina Medina-Gomez, Keri L. Monda, May E. Montasser, Gabriele Mueller, Martina Mueller-Nurasyid, Ilja M. Nolte, Kalliope Panoutsopoulou, Laura Pascoe, Lavinia Paternoster, Nigel W. Rayner, Frida Renstrom, Federica Rizzi, Lynda M. Rose, Kathy A. Ryan, Perttu Salo, Serena Sanna, Hubert Scharnagl, Jianxin Shi, Albert Vernon Smith, Lorraine Southam, Alena Stancakova, Valgerdur Steinthorsdottir, Rona J. Strawbridge, Yun Ju Sung, Ioanna Tachmazidou, Toshiko Tanaka, Gudmar Thorleifsson, Stella Trompet, Natalia Pervjakova, Jonathan P. Tyrer, Liesbeth Vandenput, Sander W. van der Laan, Nathalie van der Velde, Jessica van Setten, Jana V. van Vliet-Ostaptchouk, Niek Verweij, Efthymia Vlachopoulou, Lindsay L. Waite, Sophie R. Wang, Zhaoming Wang, Sarah H. Wild, Christina Willenborg, James F. Wilson, Andrew Wong, Jian Yang, Loic Yengo, Laura M. Yerges-Armstrong, Lei Yu, Weihua Zhang, Jing Hua Zhao, Ehm A. Andersson, Stephan J. L. Bakker, Damiano Baldassarre, Karina Banasik, Matteo Barcella, Cristina Barlassina, Claire Bellis, Paola Benaglio, John Blangero, Matthias Blueher, Fabrice Bonnet, Lori L. Bonnycastle, Heather A. Boyd, Marcel Bruinenberg, Aron S. Buchman, Harry Campbell, Yii-Der Ida Chen, Peter S. Chines, Simone Claudi-Boehm, John Cole, Francis S. Collins, Eco J. C. de Geus, Lisette C. P. G. M. de Groot, Maria Dimitriou, Jubao Duan, Stefan Enroth, Elodie Eury, Aliki-Eleni Farmaki, Nita G. Forouhi, Nele Friedrich, Pablo V. Gejman, Bruna Gigante, Nicola Glorioso, Alan S. Go, Omri Gottesman, Juergen Graessler, Harald Grallert, Niels Grarup, Yu-Mei Gu, Linda Broer, Annelies C. Ham, Torben Hansen, Tamara B. Harris, Catharina A. Hartman, Maija Hassinen, Nicholas Hastie, Andrew T. Hattersley, Andrew C. Heath, Anjali K. Henders, Dena Hernandez, Hans Hillege, Oddgeir Holmen, Kees G. Hovingh, Jennie Hui, Lise L. Husemoen, Nina Hutri-Kahonen, Pirro G. Hysi, Thomas Illig, Philip L. De Jager, Shapour Jalilzadeh, Torben Jorgensen, J. Wouter Jukema, Markus Juonala, Stavroula Kanoni, Maria Karaleftheri, Kay Tee Khaw, Leena Kinnunen, Steven J. Kittner, Wolfgang Koenig, Ivana Kolcic, Peter Kovacs, Nikolaj T. Krarup, Wolfgang Kratzer, Janine Krueger, Diana Kuh, Meena Kumari, Theodosios Kyriakou, Claudia Langenberg, Lars Lannfelt, Chiara Lanzani, Vaneet Lotay, Lenore J. Launer, Karin Leander, Jaana Lindstrom, Allan Linneberg, Yan-Ping Liu, Stephane Lobbens, Robert Luben, Valeriya Lyssenko, Satu Mannisto, Patrik K. Magnusson, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Lili Milani, Grant W. Montgomery, Andrew P. Morris, Narisu Narisu, Mari Nelis, Ken K. Ong, Aarno Palotie, Louis Perusse, Irene Pichler, Maria G. Pilia, Anneli Pouta, Myriam Rheinberger, Rasmus Ribel-Madsen, Marcus Richards, Kenneth M. Rice, Treva K. Rice, Carlo Rivolta, Veikko Salomaa, Alan R. Sanders, Mark A. Sarzynski, Salome Scholtens, Robert A. Scott, William R. Scott, Sylvain Sebert, Sebanti Sengupta, Bengt Sennblad, Thomas Seufferlein, Angela Silveira, P. Eline Slagboom, Jan H. Smit, Thomas H. Sparso, Kathleen Stirrups, Ronald P. Stolk, Heather M. Stringham, Morris A. Swertz, Amy J. Swift, Ann-Christine Syvanen, Sian-Tsung Tan, Barbara Thorand, Anke Toenjes, Angelo Tremblay, Emmanouil Tsafantakis, Peter J. van der Most, Uwe Voelker, Marie-Claude Vohl, Judith M. Vonk, Melanie Waldenberger, Ryan W. Walker, Roman Wennauer, Elisabeth Widen, Gonneke Willemsen, Tom Wilsgaard, Alan F. Wright, M. Carola Zillikens, Suzanne C. van Dijk, Natasja M. van Schoor, Folkert W. Asselbergs, Paul I. W. de Bakker, Jacques S. Beckmann, John Beilby, David A. Bennett, Richard N. Bergman, Sven Bergmann, Carsten A. Boeger, Bernhard O. Boehm, Eric Boerwinkle, Dorret I. Boomsma, Stefan R. Bornstein, Erwin P. Bottinger, Claude Bouchard, John C. Chambers, Stephen J. Chanock, Daniel I. Chasman, Francesco Cucca, Daniele Cusi, George Dedoussis, Jeanette Erdmann, Johan G. Eriksson, Denis A. Evans, Ulf de Faire, Martin Farrall, Luigi Ferrucci, Ian Ford, Lude Franke, Paul W. Franks, Philippe Froguel, Ron T. Gansevoort, Christian Gieger, Henrik Gronberg, Vilmundur Gudnason, Ulf Gyllensten, Per Hall, Anders Hamsten, Pim van der Harst, Caroline Hayward, Markku Heliovaara, Christian Hengstenberg, Andrew A. Hicks, Aroon Hingorani, Albert Hofman, Frank Hu, Heikki V. Huikuri, Kristian Hveem, Alan L. James, Joanne M. Jordan, Antti Jula, Mika Kaehoenen, Eero Kajantie, Sekar Kathiresan, Lambertus A. L. M. Kiemeney, Mika Kivimaki, Paul B. Knekt, Heikki A. Koistinen, Jaspal S. Kooner, Seppo Koskinen, Johanna Kuusisto, Winfried Maerz, Nicholas G. Martin, Markku Laakso, Timo A. Lakka, Terho Lehtimaki, Guillaume Lettre, Douglas F. Levinson, Lars Lind, Marja-Liisa Lokki, Pekka Mantyselka, Mads Melbye, Andres Metspalu, Braxton D. Mitchell, Frans L. Moll, Jeffrey C. Murray, Arthur W. Musk, Markku S. Nieminen, Inger Njolstad, Claes Ohlsson, Albertine J. Oldehinkel, Ben A. Oostra, Lyle J. Palmer, James S. Pankow, Gerard Pasterkamp, Nancy L. Pedersen, Oluf Pedersen, Brenda W. Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P. Pramstaller, Bruce M. Psaty, Lu Qi, Thomas Quertermous, Olli T. Raitakari, Tuomo Rankinen, Rainer Rauramaa, Paul M. Ridker, John D. Rioux, Fernando Rivadeneira, Jerome I. Rotter, Igor Rudan, Hester M. den Ruijter, Juha Saltevo, Naveed Sattar, Heribert Schunkert, Peter E. H. Schwarz, Alan R. Shuldiner, Juha Sinisalo, Harold Snieder, Thorkild I. A. Sorensen, Tim D. Spector, Jan A. Staessen, Bandinelli Stefania, Unnur Thorsteinsdottir, Michael Stumvoll, Jean-Claude Tardif, Elena Tremoli, Jaakko Tuomilehto, Andre G. Uitterlinden, Matti Uusitupa, Andre L. M. Verbeek, Sita H. Vermeulen, Jorma S. Viikari, Veronique Vitart, Henry Voelzke, Peter Vollenweider, Gerard Waeber, Mark Walker, Henri Wallaschofski, Nicholas J. Wareham, Hugh Watkins, Eleftheria Zeggini, Aravinda Chakravarti, Deborah J. Clegg, L. Adrienne Cupples, Penny Gordon-Larsen, Cashell E. Jaquish, D. C. Rao, Goncalo R. Abecasis, Themistocles L. Assimes, Ines Barroso, Sonja I. Berndt, Michael Boehnke, Panos Deloukas, Caroline S. Fox, Leif C. Groop, David J. Hunter, Erik Ingelsson, Robert C. Kaplan, Mark I. McCarthy, Karen L. Mohlke, Jeffrey R. O'Connell, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Joel N. Hirschhorn, Cecilia M. Lindgren, Iris M. Heid, Kari E. North, Ingrid B. Borecki, Zoltan Kutalik, Ruth J. F. Loos

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article numbere1005378
JournalPlos Genetics
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2015

Cite this

Winkler, T. W., Justice, A. E., Graff, M., Barata, L., Feitosa, M. F., Chu, S., Czajkowski, J., Esko, T., Fall, T., Kilpelainen, T. O., Lu, Y., Magi, R., Mihailov, E., Pers, T. H., Rueeger, S., Teumer, A., Ehret, G. B., Ferreira, T., Heard-Costa, N. L., ... Loos, R. J. F. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Plos Genetics, 11(10), [e1005378]. https://doi.org/10.1371/journal.pgen.1005378