The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent

Suzanna M. van Walraven; Anneke Brand; Jack N. A. Bakker; Martin B. A. Heemskerk; Suzan Nillesen; Marc B. Bierings; Laura B. Bungener; Bouke G. Hepkema; Arjan Lankester; Arnold van der Meer; Kees Sintnicolaas; Judith A. E. Somers; Eric Spierings; Marcel G. J. Tilanus; Christien E. M. Voorter; Jan J. Cornelissen; Machteld Oudshoorn

doi:10.3324/haematol.2016.145730

The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent

Suzanna M. van Walraven^*, Anneke Brand, Jack N. A. Bakker, Martin B. A. Heemskerk, Suzan Nillesen, Marc B. Bierings, Laura B. Bungener, Bouke G. Hepkema, Arjan Lankester, Arnold van der Meer, Kees Sintnicolaas, Judith A. E. Somers, Eric Spierings, Marcel G. J. Tilanus, Christien E. M. Voorter, Jan J. Cornelissen, Machteld Oudshoorn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001-2006, n=995; 2007-2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were 'donor found' and 'transplantation reached'. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (P

Original language	English
Pages (from-to)	176-183
Number of pages	8
Journal	Haematologica-the Hematology Journal
Volume	102
Issue number	1
DOIs	https://doi.org/10.3324/haematol.2016.145730
Publication status	Published - Jan 2017

Keywords

HEMATOPOIETIC-CELL TRANSPLANTATION
CORD BLOOD TRANSPLANTATION
HLA MATCH
HEMATOLOGIC MALIGNANCY
OUTCOMES
SEARCH
ALLELE
AVAILABILITY
ENGRAFTMENT
GENERATION

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Cite this

van Walraven, S. M., Brand, A., Bakker, J. N. A., Heemskerk, M. B. A., Nillesen, S., Bierings, M. B., Bungener, L. B., Hepkema, B. G., Lankester, A., van der Meer, A., Sintnicolaas, K., Somers, J. A. E., Spierings, E., Tilanus, M. G. J., Voorter, C. E. M., Cornelissen, J. J., & Oudshoorn, M. (2017). The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent. Haematologica-the Hematology Journal, 102(1), 176-183. https://doi.org/10.3324/haematol.2016.145730

@article{4235ec3f2c0b4775bffa1773687c61ec,

title = "The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent",

abstract = "Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001-2006, n=995; 2007-2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were 'donor found' and 'transplantation reached'. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (P",

keywords = "HEMATOPOIETIC-CELL TRANSPLANTATION, CORD BLOOD TRANSPLANTATION, HLA MATCH, HEMATOLOGIC MALIGNANCY, OUTCOMES, SEARCH, ALLELE, AVAILABILITY, ENGRAFTMENT, GENERATION",

author = "{van Walraven}, {Suzanna M.} and Anneke Brand and Bakker, {Jack N. A.} and Heemskerk, {Martin B. A.} and Suzan Nillesen and Bierings, {Marc B.} and Bungener, {Laura B.} and Hepkema, {Bouke G.} and Arjan Lankester and {van der Meer}, Arnold and Kees Sintnicolaas and Somers, {Judith A. E.} and Eric Spierings and Tilanus, {Marcel G. J.} and Voorter, {Christien E. M.} and Cornelissen, {Jan J.} and Machteld Oudshoorn",

year = "2017",

month = jan,

doi = "10.3324/haematol.2016.145730",

language = "English",

volume = "102",

pages = "176--183",

journal = "Haematologica-the Hematology Journal",

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van Walraven, SM, Brand, A, Bakker, JNA, Heemskerk, MBA, Nillesen, S, Bierings, MB, Bungener, LB, Hepkema, BG, Lankester, A, van der Meer, A, Sintnicolaas, K, Somers, JAE, Spierings, E, Tilanus, MGJ, Voorter, CEM, Cornelissen, JJ & Oudshoorn, M 2017, 'The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent', Haematologica-the Hematology Journal, vol. 102, no. 1, pp. 176-183. https://doi.org/10.3324/haematol.2016.145730

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AU - Brand, Anneke

AU - Bakker, Jack N. A.

AU - Heemskerk, Martin B. A.

AU - Nillesen, Suzan

AU - Bierings, Marc B.

AU - Bungener, Laura B.

AU - Hepkema, Bouke G.

AU - Lankester, Arjan

AU - van der Meer, Arnold

AU - Sintnicolaas, Kees

AU - Somers, Judith A. E.

AU - Spierings, Eric

AU - Tilanus, Marcel G. J.

AU - Voorter, Christien E. M.

AU - Cornelissen, Jan J.

AU - Oudshoorn, Machteld

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N2 - Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001-2006, n=995; 2007-2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were 'donor found' and 'transplantation reached'. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (P

AB - Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001-2006, n=995; 2007-2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were 'donor found' and 'transplantation reached'. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (P

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KW - CORD BLOOD TRANSPLANTATION

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KW - HEMATOLOGIC MALIGNANCY

KW - OUTCOMES

KW - SEARCH

KW - ALLELE

KW - AVAILABILITY

KW - ENGRAFTMENT

KW - GENERATION

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DO - 10.3324/haematol.2016.145730

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SN - 0390-6078

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