The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent

Suzanna M. van Walraven*, Anneke Brand, Jack N. A. Bakker, Martin B. A. Heemskerk, Suzan Nillesen, Marc B. Bierings, Laura B. Bungener, Bouke G. Hepkema, Arjan Lankester, Arnold van der Meer, Kees Sintnicolaas, Judith A. E. Somers, Eric Spierings, Marcel G. J. Tilanus, Christien E. M. Voorter, Jan J. Cornelissen, Machteld Oudshoorn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Web of Science)

Abstract

Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001-2006, n=995; 2007-2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were 'donor found' and 'transplantation reached'. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (P

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalHaematologica-the Hematology Journal
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 2017

Keywords

  • HEMATOPOIETIC-CELL TRANSPLANTATION
  • CORD BLOOD TRANSPLANTATION
  • HLA MATCH
  • HEMATOLOGIC MALIGNANCY
  • OUTCOMES
  • SEARCH
  • ALLELE
  • AVAILABILITY
  • ENGRAFTMENT
  • GENERATION

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