The Importance of Muscle Capillarization for Optimizing Satellite Cell Plasticity

J.P. Nederveen, M.W. Betz, T. Snijders, G. Parise*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

Satellite cells are essential for skeletal muscle regeneration, repair, and adaptation. The activity of satellite cells is influenced by their interactions with muscle-resident endothelial cells. We postulate that the microvascular network between muscle fibers plays a critical role in satellite cell function. Exercise-induced angiogenesis can mitigate the decline in satellite cell function with age.
Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalExercise and Sport Sciences Reviews
Volume49
Issue number4
DOIs
Publication statusPublished - 1 Oct 2021

Keywords

  • satellite cells
  • capillarization
  • endothelial cells
  • skeletal muscle
  • regeneration
  • HUMAN SKELETAL-MUSCLE
  • RESISTANCE EXERCISE
  • ENDOTHELIAL-CELLS
  • REGENERATION
  • VEGF
  • ANGIOGENESIS
  • AGE
  • REJUVENATION
  • MYOGENESIS
  • EXPANSION

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