The Importance of Muscle Capillarization for Optimizing Satellite Cell Plasticity

J.P. Nederveen, M.W. Betz, T. Snijders, G. Parise*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Web of Science)
35 Downloads (Pure)

Abstract

Satellite cells are essential for skeletal muscle regeneration, repair, and adaptation. The activity of satellite cells is influenced by their interactions with muscle-resident endothelial cells. We postulate that the microvascular network between muscle fibers plays a critical role in satellite cell function. Exercise-induced angiogenesis can mitigate the decline in satellite cell function with age.
Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalExercise and Sport Sciences Reviews
Volume49
Issue number4
DOIs
Publication statusPublished - 1 Oct 2021

Keywords

  • satellite cells
  • capillarization
  • endothelial cells
  • skeletal muscle
  • regeneration
  • HUMAN SKELETAL-MUSCLE
  • RESISTANCE EXERCISE
  • ENDOTHELIAL-CELLS
  • REGENERATION
  • VEGF
  • ANGIOGENESIS
  • AGE
  • REJUVENATION
  • MYOGENESIS
  • EXPANSION

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