The impact of surgical aortic valve replacement on quality of life-a multicenter study

Fredrike Blokzijl*, Saskia Houterman, Bart H M van Straten, Edgar Daeter, George J Brandon Bravo Bruinsma, Willem Dieperink, Michiel F Reneman, Frederik Keus, Iwan C C van der Horst, Massimo A Mariani

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVES: To explore the effect of surgical aortic valve replacement on quality of life and the variance with age, particularly in patients at risk of deterioration.

METHODS: In an observational, multicenter, cohort study of routinely collected health data, patients undergoing and electively operated between January 2011 and January 2015 with pre- and postoperative quality of life data were included. Patients were classified into 3 age groups: <65, 65-79, and ≥80 years. Quality of life was measured at baseline and at 1-year follow-up using the Short-Form Health Survey-12 or SF-36. We defined a >5-point difference as a minimal clinically important difference. Multivariable linear regression analysis, with adjustment for confounders, was used to evaluate the association between age and quality of life.

RESULTS: In 899 patients, mean physical health increased from 55 to 66 and mental health from 60 to 66. A minimal clinically important decreased physical health was observed in 12% of patients aged <65 years, 16% of patients aged 65-79 years, and 22% of patients aged ≥80 years (P = .023). A decreased mental health was observed in 15% of patients aged <65 years, 22% of patients aged 65-79 years, and 24% aged ≥80 years (P = .030). Older age and a greater physical and mental score at baseline were associated with a decreased physical and mental quality of life (P < .001).

CONCLUSIONS: Patients surviving surgical aortic valve replacement on average improve in physical and mental quality of life; nonetheless, with increasing age patients are at higher risk of experiencing a deterioration.

Original languageEnglish
Pages (from-to)1204-1210.e7
Number of pages14
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number4
Early online date31 Oct 2019
Publication statusPublished - Apr 2021


  • surgical aortic valve replacement
  • quality of life
  • patient-reported outcomes

Cite this