The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy

P. J. A. van Nuland; J. Halim; D. J. van Ginkel; D. C. Overduin; J. Brouwer; V. J. Nijenhuis; A. W. J. van't Hof; P. A. L. Tonino; J. M. ten Berg; P. A. Vriesendorp

doi:10.1002/ccd.31431

The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy

P. J. A. van Nuland, J. Halim^*, D. J. van Ginkel, D. C. Overduin, J. Brouwer, V. J. Nijenhuis, A. W. J. van't Hof, P. A. L. Tonino, J. M. ten Berg, P. A. Vriesendorp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BackgroundConduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). Data regarding its impact on mortality and morbidity are conflicting. This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health-related Quality of Life (QoL) during the first year after TAVI.MethodsIn this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, n = 779), PPI before TAVI (PPI pre-TAVI, n = 102), PPI within 30 days after TAVI (PPI post-TAVI, n = 97). All-cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF-12 and EQ-5D-5L questionnaires at baseline and 3, 6, and 12 months.ResultsAt 1-year, all-cause death was seen in 6.9% (PPI pre-TAVI, p = 0.53) and 10.3% (PPI post-TAVI, p = 0.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre-TAVI, p = 0.58) and 6.2% (PPI post-TAVI, p = 0.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre-TAVI group showed lower PCS-12 over time compared to the no PPI group (p = 0.04), while MCS-12, EQ-5D Index and EQ-5D VAS scores were equal. No significant differences in QoL were seen between the PPI post-TAVI group and the no PPI group.ConclusionPPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre-TAVI was associated with lower physical QoL.

Original language	English
Number of pages	10
Journal	Catheterization and Cardiovascular interventions
DOIs	https://doi.org/10.1002/ccd.31431
Publication status	E-pub ahead of print - 1 Jan 2025

Keywords

mortality
permanent pacemaker implantation
quality of life
transcatheter aortic valve implantation
AORTIC-VALVE-REPLACEMENT
CLINICAL-OUTCOMES
HEART-FAILURE
TRANSCATHETER
PREDICTORS
REGURGITATION
ATRIAL
TRIAL

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van Nuland, P. J. A., Halim, J., van Ginkel, D. J., Overduin, D. C., Brouwer, J., Nijenhuis, V. J., van't Hof, A. W. J., Tonino, P. A. L., ten Berg, J. M., & Vriesendorp, P. A. (2025). The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy. Catheterization and Cardiovascular interventions. Advance online publication. https://doi.org/10.1002/ccd.31431

@article{ad804bfa9b0045c4a7131c3d17da1068,

title = "The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy",

abstract = "BackgroundConduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). Data regarding its impact on mortality and morbidity are conflicting. This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health-related Quality of Life (QoL) during the first year after TAVI.MethodsIn this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, n = 779), PPI before TAVI (PPI pre-TAVI, n = 102), PPI within 30 days after TAVI (PPI post-TAVI, n = 97). All-cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF-12 and EQ-5D-5L questionnaires at baseline and 3, 6, and 12 months.ResultsAt 1-year, all-cause death was seen in 6.9% (PPI pre-TAVI, p = 0.53) and 10.3% (PPI post-TAVI, p = 0.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre-TAVI, p = 0.58) and 6.2% (PPI post-TAVI, p = 0.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre-TAVI group showed lower PCS-12 over time compared to the no PPI group (p = 0.04), while MCS-12, EQ-5D Index and EQ-5D VAS scores were equal. No significant differences in QoL were seen between the PPI post-TAVI group and the no PPI group.ConclusionPPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre-TAVI was associated with lower physical QoL.",

keywords = "mortality, permanent pacemaker implantation, quality of life, transcatheter aortic valve implantation, AORTIC-VALVE-REPLACEMENT, CLINICAL-OUTCOMES, HEART-FAILURE, TRANSCATHETER, PREDICTORS, REGURGITATION, ATRIAL, TRIAL",

author = "{van Nuland}, {P. J. A.} and J. Halim and {van Ginkel}, {D. J.} and Overduin, {D. C.} and J. Brouwer and Nijenhuis, {V. J.} and {van't Hof}, {A. W. J.} and Tonino, {P. A. L.} and {ten Berg}, {J. M.} and Vriesendorp, {P. A.}",

year = "2025",

month = jan,

day = "1",

doi = "10.1002/ccd.31431",

language = "English",

journal = "Catheterization and Cardiovascular interventions",

issn = "1522-1946",

publisher = "John Wiley & Sons Inc.",

}

TY - JOUR

T1 - The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life

T2 - A POPular TAVI Substudy

AU - van Nuland, P. J. A.

AU - Halim, J.

AU - van Ginkel, D. J.

AU - Overduin, D. C.

AU - Brouwer, J.

AU - Nijenhuis, V. J.

AU - van't Hof, A. W. J.

AU - Tonino, P. A. L.

AU - ten Berg, J. M.

AU - Vriesendorp, P. A.

PY - 2025/1/1

Y1 - 2025/1/1

N2 - BackgroundConduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). Data regarding its impact on mortality and morbidity are conflicting. This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health-related Quality of Life (QoL) during the first year after TAVI.MethodsIn this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, n = 779), PPI before TAVI (PPI pre-TAVI, n = 102), PPI within 30 days after TAVI (PPI post-TAVI, n = 97). All-cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF-12 and EQ-5D-5L questionnaires at baseline and 3, 6, and 12 months.ResultsAt 1-year, all-cause death was seen in 6.9% (PPI pre-TAVI, p = 0.53) and 10.3% (PPI post-TAVI, p = 0.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre-TAVI, p = 0.58) and 6.2% (PPI post-TAVI, p = 0.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre-TAVI group showed lower PCS-12 over time compared to the no PPI group (p = 0.04), while MCS-12, EQ-5D Index and EQ-5D VAS scores were equal. No significant differences in QoL were seen between the PPI post-TAVI group and the no PPI group.ConclusionPPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre-TAVI was associated with lower physical QoL.

AB - BackgroundConduction disturbances are common after transcatheter aortic valve implantation (TAVI) and frequently require permanent pacemaker implantation (PPI). Data regarding its impact on mortality and morbidity are conflicting. This study aims to assess the impact of PPI before or within 30 days after TAVI on mortality and health-related Quality of Life (QoL) during the first year after TAVI.MethodsIn this POPular TAVI substudy, 978 patients were included and categorized into three groups: Neither PPI before or within 30 days after TAVI (no PPI, n = 779), PPI before TAVI (PPI pre-TAVI, n = 102), PPI within 30 days after TAVI (PPI post-TAVI, n = 97). All-cause death and cardiac death were evaluated at 1 year. QoL was assessed using the SF-12 and EQ-5D-5L questionnaires at baseline and 3, 6, and 12 months.ResultsAt 1-year, all-cause death was seen in 6.9% (PPI pre-TAVI, p = 0.53) and 10.3% (PPI post-TAVI, p = 0.66) of the patients compared to 8.7% of the patients (no PPI). Cardiac death was observed in 4.9% (PPI pre-TAVI, p = 0.58) and 6.2% (PPI post-TAVI, p = 0.94) of the patients compared to 6.2% of patients (no PPI). Regarding QoL, the PPI pre-TAVI group showed lower PCS-12 over time compared to the no PPI group (p = 0.04), while MCS-12, EQ-5D Index and EQ-5D VAS scores were equal. No significant differences in QoL were seen between the PPI post-TAVI group and the no PPI group.ConclusionPPI before or within 30 days after TAVI was not associated with increased mortality within 1 year. PPI pre-TAVI was associated with lower physical QoL.

KW - mortality

KW - permanent pacemaker implantation

KW - quality of life

KW - transcatheter aortic valve implantation

KW - AORTIC-VALVE-REPLACEMENT

KW - CLINICAL-OUTCOMES

KW - HEART-FAILURE

KW - TRANSCATHETER

KW - PREDICTORS

KW - REGURGITATION

KW - ATRIAL

KW - TRIAL

U2 - 10.1002/ccd.31431

DO - 10.1002/ccd.31431

M3 - Article

SN - 1522-1946

JO - Catheterization and Cardiovascular interventions

JF - Catheterization and Cardiovascular interventions

ER -

The Impact of Permanent Pacemaker Implantation After TAVI on Mortality and Quality of Life: A POPular TAVI Substudy

Abstract

Keywords

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