The impact of MTHFR 677C -> T risk knowledge on changes in folate intake: findings from the Food4Me study

Clare B. O'Donovan; Marianne C. Walsh; Hannah Forster; Clara Woolhead; Carlos Celis-Morales; Rosalind Fallaize; Anna L. Macready; Cyril F. M. Marsaux; Santiago Navas-Carretero; Rodrigo San-Cristobal; Silvia Kolossa; Christina Mavrogianni; Christina P. Lambrinou; George Moschonis; Magdalena Godlewska; Agnieszka Surwillo; Jildau Bouwman; Keith Grimaldi; Iwona Traczyk; Christian A. Drevon; Hannelore Daniel; Yannis Manios; J. Alfredo Martinez; Wim H. M. Saris; Julie A. Lovegrove; John C. Mathers; Michael J. Gibney; Lorraine Brennan; Eileen R. Gibney

doi:10.1186/s12263-016-0539-x

The impact of MTHFR 677C -> T risk knowledge on changes in folate intake: findings from the Food4Me study

Clare B. O'Donovan, Marianne C. Walsh, Hannah Forster, Clara Woolhead, Carlos Celis-Morales, Rosalind Fallaize, Anna L. Macready, Cyril F. M. Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Jildau Bouwman, Keith Grimaldi, Iwona Traczyk, Christian A. DrevonHannelore Daniel, Yannis Manios, J. Alfredo Martinez, Wim H. M. Saris, Julie A. Lovegrove, John C. Mathers, Michael J. Gibney, Lorraine Brennan, Eileen R. Gibney^*

^*Corresponding author for this work

Humane Biologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention. Results: There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p = 0.010). Baseline folate intakes were 412 +/- 172, 391 +/- 190 and 410 +/- 186 mu g per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate. Conclusions: These results suggest that knowledge of MTHFR 677C -> T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.

Original language	English
Article number	25
Journal	Genes and nutrition
Volume	11
DOIs	https://doi.org/10.1186/s12263-016-0539-x
Publication status	Published - 29 Sept 2016

Keywords

MTHFR
Methylenetetrahydrofolate reductase 677C -> T genotype
Genetic risk knowledge
Folate
Personalised nutrition

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Cite this

O'Donovan, C. B., Walsh, M. C., Forster, H., Woolhead, C., Celis-Morales, C., Fallaize, R., Macready, A. L., Marsaux, C. F. M., Navas-Carretero, S., San-Cristobal, R., Kolossa, S., Mavrogianni, C., Lambrinou, C. P., Moschonis, G., Godlewska, M., Surwillo, A., Bouwman, J., Grimaldi, K., Traczyk, I., ... Gibney, E. R. (2016). The impact of MTHFR 677C -> T risk knowledge on changes in folate intake: findings from the Food4Me study. Genes and nutrition, 11, Article 25. https://doi.org/10.1186/s12263-016-0539-x

@article{b8c37c99e4f148a999636414a2f6dbef,

title = "The impact of MTHFR 677C -> T risk knowledge on changes in folate intake: findings from the Food4Me study",

abstract = "Background: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention. Results: There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p = 0.010). Baseline folate intakes were 412 +/- 172, 391 +/- 190 and 410 +/- 186 mu g per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate. Conclusions: These results suggest that knowledge of MTHFR 677C -> T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.",

keywords = "MTHFR, Methylenetetrahydrofolate reductase 677C -> T genotype, Genetic risk knowledge, Folate, Personalised nutrition",

author = "O'Donovan, {Clare B.} and Walsh, {Marianne C.} and Hannah Forster and Clara Woolhead and Carlos Celis-Morales and Rosalind Fallaize and Macready, {Anna L.} and Marsaux, {Cyril F. M.} and Santiago Navas-Carretero and Rodrigo San-Cristobal and Silvia Kolossa and Christina Mavrogianni and Lambrinou, {Christina P.} and George Moschonis and Magdalena Godlewska and Agnieszka Surwillo and Jildau Bouwman and Keith Grimaldi and Iwona Traczyk and Drevon, {Christian A.} and Hannelore Daniel and Yannis Manios and Martinez, {J. Alfredo} and Saris, {Wim H. M.} and Lovegrove, {Julie A.} and Mathers, {John C.} and Gibney, {Michael J.} and Lorraine Brennan and Gibney, {Eileen R.}",

year = "2016",

month = sep,

day = "29",

doi = "10.1186/s12263-016-0539-x",

language = "English",

volume = "11",

journal = "Genes and nutrition",

issn = "1555-8932",

publisher = "BioMed Central Ltd",

}

O'Donovan, CB, Walsh, MC, Forster, H, Woolhead, C, Celis-Morales, C, Fallaize, R, Macready, AL, Marsaux, CFM, Navas-Carretero, S, San-Cristobal, R, Kolossa, S, Mavrogianni, C, Lambrinou, CP, Moschonis, G, Godlewska, M, Surwillo, A, Bouwman, J, Grimaldi, K, Traczyk, I, Drevon, CA, Daniel, H, Manios, Y, Martinez, JA, Saris, WHM, Lovegrove, JA, Mathers, JC, Gibney, MJ, Brennan, L & Gibney, ER 2016, 'The impact of MTHFR 677C -> T risk knowledge on changes in folate intake: findings from the Food4Me study', Genes and nutrition, vol. 11, 25. https://doi.org/10.1186/s12263-016-0539-x

TY - JOUR

T1 - The impact of MTHFR 677C -> T risk knowledge on changes in folate intake: findings from the Food4Me study

AU - O'Donovan, Clare B.

AU - Walsh, Marianne C.

AU - Forster, Hannah

AU - Woolhead, Clara

AU - Celis-Morales, Carlos

AU - Fallaize, Rosalind

AU - Macready, Anna L.

AU - Marsaux, Cyril F. M.

AU - Navas-Carretero, Santiago

AU - San-Cristobal, Rodrigo

AU - Kolossa, Silvia

AU - Mavrogianni, Christina

AU - Lambrinou, Christina P.

AU - Moschonis, George

AU - Godlewska, Magdalena

AU - Surwillo, Agnieszka

AU - Bouwman, Jildau

AU - Grimaldi, Keith

AU - Traczyk, Iwona

AU - Drevon, Christian A.

AU - Daniel, Hannelore

AU - Manios, Yannis

AU - Martinez, J. Alfredo

AU - Saris, Wim H. M.

AU - Lovegrove, Julie A.

AU - Mathers, John C.

AU - Gibney, Michael J.

AU - Brennan, Lorraine

AU - Gibney, Eileen R.

PY - 2016/9/29

Y1 - 2016/9/29

N2 - Background: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention. Results: There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p = 0.010). Baseline folate intakes were 412 +/- 172, 391 +/- 190 and 410 +/- 186 mu g per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate. Conclusions: These results suggest that knowledge of MTHFR 677C -> T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.

AB - Background: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention. Results: There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p = 0.010). Baseline folate intakes were 412 +/- 172, 391 +/- 190 and 410 +/- 186 mu g per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate. Conclusions: These results suggest that knowledge of MTHFR 677C -> T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.

KW - MTHFR

KW - Methylenetetrahydrofolate reductase 677C -> T genotype

KW - Genetic risk knowledge

KW - Folate

KW - Personalised nutrition

U2 - 10.1186/s12263-016-0539-x

DO - 10.1186/s12263-016-0539-x

M3 - Article

SN - 1555-8932

VL - 11

JO - Genes and nutrition

JF - Genes and nutrition

M1 - 25

ER -