The Impact of Inadequate Temperature Storage Conditions on Aggregate and Particle Formation in Drugs Containing Tumor Necrosis Factor-Alpha Inhibitors

N. D. Vlieland, M. R. Nejadnik, H. Gardarsdottir*, S. Romeijn, A. S. Sediq, M. L. Bouvy, A. C. G. Egberts, B. J. F. van den Bemt, W. Jiskoot

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number42
Number of pages11
JournalPharmaceutical Research
Volume35
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • aggregation of antibodies
  • drug product characterization
  • freezing stress conditions
  • home storage
  • TNF-alpha inhibitors
  • MONOCLONAL-ANTIBODY
  • IMMUNOGENICITY
  • PROTEINS
  • PRODUCT

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