The Impact of Inadequate Temperature Storage Conditions on Aggregate and Particle Formation in Drugs Containing Tumor Necrosis Factor-Alpha Inhibitors

N. D. Vlieland, M. R. Nejadnik, H. Gardarsdottir, S. Romeijn, A. S. Sediq, M. L. Bouvy, A. C. G. Egberts, B. J. F. van den Bemt, W. Jiskoot

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number42
Number of pages11
JournalPharmaceutical Research
Volume35
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • aggregation of antibodies
  • drug product characterization
  • freezing stress conditions
  • home storage
  • TNF-alpha inhibitors
  • MONOCLONAL-ANTIBODY
  • IMMUNOGENICITY
  • PROTEINS
  • PRODUCT

Cite this

Vlieland, N. D., Nejadnik, M. R., Gardarsdottir, H., Romeijn, S., Sediq, A. S., Bouvy, M. L., Egberts, A. C. G., van den Bemt, B. J. F., & Jiskoot, W. (2018). The Impact of Inadequate Temperature Storage Conditions on Aggregate and Particle Formation in Drugs Containing Tumor Necrosis Factor-Alpha Inhibitors. Pharmaceutical Research, 35(2), [42]. https://doi.org/10.1007/s11095-017-2341-x