The impact of hypoglycaemia on quality of life outcomes among adults with type 1 diabetes: A systematic review

H. Chatwin; M. Broadley; J. Speight; A. Cantrell; A. Sutton; S. Heller; B. de Galan; C. Hendrieckx; F. Pouwer; Hypo-RESOLVE Consortium

doi:10.1016/j.diabres.2021.108752

The impact of hypoglycaemia on quality of life outcomes among adults with type 1 diabetes: A systematic review

H. Chatwin^*, M. Broadley, J. Speight, A. Cantrell, A. Sutton, S. Heller, B. de Galan, C. Hendrieckx, F. Pouwer, Hypo-RESOLVE Consortium

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Hypoglycaemia is a common barrier to optimal glycaemic management and often feared among adults with type 1 diabetes. The aim of this systematic review was to summarize current evidence regarding the impact of hypoglycaemia on quality of life (QoL) and related outcomes. Electronic searches of MEDLINE, PsycINFO, CINAHL, Cochrane Database of Sys-tematic Reviews, and Cochrane Central Register of Controlled Trials were conducted. Peer-reviewed empirical studies investigating the relationship between hypoglycaemia and QoL were eligible for inclusion. Thirty studies met the inclusion criteria. Extracted data was summarized in a narrative synthesis according to Synthesis Without Meta-Analysis guide-lines. None of the studies examined the impact of hypoglycaemia on general QoL. There was no association between hypoglycaemia and diabetes-specific QoL in four of the 30 studies. Severe hypoglycaemia was associated with greater fear of hypoglycaemia and dia-betes distress, and lower general emotional well-being, but not with depression, anxiety, or health status. Self-treated hypoglycaemia was associated with greater fear of hypogly-caemia. With the exception of fear of hypoglycaemia, this review shows mixed associations between hypoglycaemia and psychological outcomes. Further research is needed to inves-tigate the impact of hypoglycaemia on other domains of QoL.(c) 2021 Elsevier B.V. All rights reserved.

Original language	English
Article number	108752
Number of pages	10
Journal	Diabetes Research and Clinical Practice
Volume	174
DOIs	https://doi.org/10.1016/j.diabres.2021.108752
Publication status	Published - 1 Apr 2021

Keywords

Type 1 diabetes
T1DM
Hypoglycaemia
Low blood glucose
Quality of life
Psychology
FEAR
MANAGEMENT
AWARENESS
PEOPLE

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Chatwin, H., Broadley, M., Speight, J., Cantrell, A., Sutton, A., Heller, S., de Galan, B., Hendrieckx, C., Pouwer, F., & Hypo-RESOLVE Consortium (2021). The impact of hypoglycaemia on quality of life outcomes among adults with type 1 diabetes: A systematic review. Diabetes Research and Clinical Practice, 174, Article 108752. https://doi.org/10.1016/j.diabres.2021.108752

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abstract = "Hypoglycaemia is a common barrier to optimal glycaemic management and often feared among adults with type 1 diabetes. The aim of this systematic review was to summarize current evidence regarding the impact of hypoglycaemia on quality of life (QoL) and related outcomes. Electronic searches of MEDLINE, PsycINFO, CINAHL, Cochrane Database of Sys-tematic Reviews, and Cochrane Central Register of Controlled Trials were conducted. Peer-reviewed empirical studies investigating the relationship between hypoglycaemia and QoL were eligible for inclusion. Thirty studies met the inclusion criteria. Extracted data was summarized in a narrative synthesis according to Synthesis Without Meta-Analysis guide-lines. None of the studies examined the impact of hypoglycaemia on general QoL. There was no association between hypoglycaemia and diabetes-specific QoL in four of the 30 studies. Severe hypoglycaemia was associated with greater fear of hypoglycaemia and dia-betes distress, and lower general emotional well-being, but not with depression, anxiety, or health status. Self-treated hypoglycaemia was associated with greater fear of hypogly-caemia. With the exception of fear of hypoglycaemia, this review shows mixed associations between hypoglycaemia and psychological outcomes. Further research is needed to inves-tigate the impact of hypoglycaemia on other domains of QoL.(c) 2021 Elsevier B.V. All rights reserved.",

keywords = "Type 1 diabetes, T1DM, Hypoglycaemia, Low blood glucose, Quality of life, Psychology, FEAR, MANAGEMENT, AWARENESS, PEOPLE",

author = "H. Chatwin and M. Broadley and J. Speight and A. Cantrell and A. Sutton and S. Heller and {de Galan}, B. and C. Hendrieckx and F. Pouwer and {Hypo-RESOLVE Consortium}",

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AU - Chatwin, H.

AU - Broadley, M.

AU - Speight, J.

AU - Cantrell, A.

AU - Sutton, A.

AU - Heller, S.

AU - de Galan, B.

AU - Hendrieckx, C.

AU - Pouwer, F.

AU - Hypo-RESOLVE Consortium

PY - 2021/4/1

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N2 - Hypoglycaemia is a common barrier to optimal glycaemic management and often feared among adults with type 1 diabetes. The aim of this systematic review was to summarize current evidence regarding the impact of hypoglycaemia on quality of life (QoL) and related outcomes. Electronic searches of MEDLINE, PsycINFO, CINAHL, Cochrane Database of Sys-tematic Reviews, and Cochrane Central Register of Controlled Trials were conducted. Peer-reviewed empirical studies investigating the relationship between hypoglycaemia and QoL were eligible for inclusion. Thirty studies met the inclusion criteria. Extracted data was summarized in a narrative synthesis according to Synthesis Without Meta-Analysis guide-lines. None of the studies examined the impact of hypoglycaemia on general QoL. There was no association between hypoglycaemia and diabetes-specific QoL in four of the 30 studies. Severe hypoglycaemia was associated with greater fear of hypoglycaemia and dia-betes distress, and lower general emotional well-being, but not with depression, anxiety, or health status. Self-treated hypoglycaemia was associated with greater fear of hypogly-caemia. With the exception of fear of hypoglycaemia, this review shows mixed associations between hypoglycaemia and psychological outcomes. Further research is needed to inves-tigate the impact of hypoglycaemia on other domains of QoL.(c) 2021 Elsevier B.V. All rights reserved.

AB - Hypoglycaemia is a common barrier to optimal glycaemic management and often feared among adults with type 1 diabetes. The aim of this systematic review was to summarize current evidence regarding the impact of hypoglycaemia on quality of life (QoL) and related outcomes. Electronic searches of MEDLINE, PsycINFO, CINAHL, Cochrane Database of Sys-tematic Reviews, and Cochrane Central Register of Controlled Trials were conducted. Peer-reviewed empirical studies investigating the relationship between hypoglycaemia and QoL were eligible for inclusion. Thirty studies met the inclusion criteria. Extracted data was summarized in a narrative synthesis according to Synthesis Without Meta-Analysis guide-lines. None of the studies examined the impact of hypoglycaemia on general QoL. There was no association between hypoglycaemia and diabetes-specific QoL in four of the 30 studies. Severe hypoglycaemia was associated with greater fear of hypoglycaemia and dia-betes distress, and lower general emotional well-being, but not with depression, anxiety, or health status. Self-treated hypoglycaemia was associated with greater fear of hypogly-caemia. With the exception of fear of hypoglycaemia, this review shows mixed associations between hypoglycaemia and psychological outcomes. Further research is needed to inves-tigate the impact of hypoglycaemia on other domains of QoL.(c) 2021 Elsevier B.V. All rights reserved.

KW - Type 1 diabetes

KW - T1DM

KW - Hypoglycaemia

KW - Low blood glucose

KW - Quality of life

KW - Psychology

KW - FEAR

KW - MANAGEMENT

KW - AWARENESS

KW - PEOPLE

U2 - 10.1016/j.diabres.2021.108752

DO - 10.1016/j.diabres.2021.108752

M3 - (Systematic) Review article

C2 - 33722700

SN - 0168-8227

VL - 174

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

M1 - 108752

ER -

The impact of hypoglycaemia on quality of life outcomes among adults with type 1 diabetes: A systematic review

Abstract

Keywords

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