The Impact of Amyloid PET Disclosure on Quality of Life in Patients With Young Onset Dementia

Daniël M van der Doelen*, Ron L H Handels, Marissa D Zwan, Sander M J van Kuijk, Wiesje Pelkmans, Femke H Bouwman, Philip Scheltens, Carmen D Dirksen, Frans R J Verhey

*Corresponding author for this work

Research output: Contribution to journalArticleAcademic

Abstract

INTRODUCTION: The impact of amyloid positron emission tomography (PET) imaging on patient health outcomes for individuals with dementia is unknown. In the present study, we explored the association between diagnostic outcome and clinician's level of certainty with quality of life (QoL) after [18F]flutemetamol PET results were disclosed in young onset dementia patients in a memory clinic cohort.

METHODS: In 154 patients suspected of dementia, QoL was measured before and after [18F]flutemetamol PET results were disclosed. Multiple regression analyses were conducted with (changed) general and disease-specific QoL measures as dependent factors [QoL-Alzheimer disease (AD) and EQ-5D Dutch tariff] and etiological diagnosis and clinician's certainty as independent factors.

RESULTS: (Change in) diagnosis of AD was associated to QOL in 2 of the 4 analyses (utility-based QoL β=0.15, P=0.010; disease-specific QoL β=2.0, P=0.037). Diagnostic certainty was associated to QOL in 1 of the 4 analyses (generic QoL β=0.002, P=0.028).

DISCUSSION: The diverse results in this explorative analysis do not reflect a univocal association between diagnosis, certainty, and QoL. Nevertheless, this result could be interpreted as a possible potential for advanced diagnostic technologies for AD, which requires confirmation in future research.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalAlzheimer Disease & Associated Disorders
Volume36
Issue number1
DOIs
Publication statusPublished - 25 Feb 2022

Keywords

  • Alzheimer disease
  • diagnosis
  • diagnostic certainty
  • quality of life
  • amyloid PET
  • ALZHEIMERS ASSOCIATION WORKGROUPS
  • DIAGNOSTIC GUIDELINES
  • NATIONAL INSTITUTE
  • DISEASE
  • UTILITY
  • RECOMMENDATIONS
  • DETERMINANTS
  • VERSION
  • PEOPLE

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