TY - JOUR
T1 - The impact of age on vascular smooth muscle function in humans
AU - Montero, David
AU - Pierce, Gary L.
AU - Stehouwer, Coen D. A.
AU - Padilla, Jaume
AU - Thijssen, Dick H. J.
PY - 2015/3
Y1 - 2015/3
N2 - Aim: Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exogenous nitric oxide donor, is typically reported to be intact, many of these studies are limited by a small sample size. Therefore, the purpose of this meta-analysis is to systematically review and determine whether vascular SMF is different between older versus young healthy individuals. Design: We conducted a systematic search of MEDLINE, Cochrane and Scopus, since their inceptions until January 2014, for articles evaluating SMF in the brachial artery and/or resistance arteries (BASMF and RASMF, respectively), as assessed by the endothelium-independent vasodilator response to exogenous nitric oxide donors in older (>= 60 years) and young (
AB - Aim: Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exogenous nitric oxide donor, is typically reported to be intact, many of these studies are limited by a small sample size. Therefore, the purpose of this meta-analysis is to systematically review and determine whether vascular SMF is different between older versus young healthy individuals. Design: We conducted a systematic search of MEDLINE, Cochrane and Scopus, since their inceptions until January 2014, for articles evaluating SMF in the brachial artery and/or resistance arteries (BASMF and RASMF, respectively), as assessed by the endothelium-independent vasodilator response to exogenous nitric oxide donors in older (>= 60 years) and young (
KW - advanced age
KW - conduit artery
KW - resistance arteries
KW - vascular smooth muscle function
U2 - 10.1097/HJH.0000000000000446
DO - 10.1097/HJH.0000000000000446
M3 - Article
C2 - 25479030
SN - 0263-6352
VL - 33
SP - 445
EP - 453
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 3
ER -