The impact of age on vascular smooth muscle function in humans

David Montero; Gary L. Pierce; Coen D. A. Stehouwer; Jaume Padilla; Dick H. J. Thijssen

doi:10.1097/HJH.0000000000000446

The impact of age on vascular smooth muscle function in humans

David Montero^*, Gary L. Pierce, Coen D. A. Stehouwer, Jaume Padilla, Dick H. J. Thijssen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim: Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exogenous nitric oxide donor, is typically reported to be intact, many of these studies are limited by a small sample size. Therefore, the purpose of this meta-analysis is to systematically review and determine whether vascular SMF is different between older versus young healthy individuals. Design: We conducted a systematic search of MEDLINE, Cochrane and Scopus, since their inceptions until January 2014, for articles evaluating SMF in the brachial artery and/or resistance arteries (BASMF and RASMF, respectively), as assessed by the endothelium-independent vasodilator response to exogenous nitric oxide donors in older (>= 60 years) and young (

Original language	English
Pages (from-to)	445-453
Journal	Journal of Hypertension
Volume	33
Issue number	3
DOIs	https://doi.org/10.1097/HJH.0000000000000446
Publication status	Published - Mar 2015

Keywords

advanced age
conduit artery
resistance arteries
vascular smooth muscle function

Access to Document

10.1097/HJH.0000000000000446

Cite this

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title = "The impact of age on vascular smooth muscle function in humans",

abstract = "Aim: Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exogenous nitric oxide donor, is typically reported to be intact, many of these studies are limited by a small sample size. Therefore, the purpose of this meta-analysis is to systematically review and determine whether vascular SMF is different between older versus young healthy individuals. Design: We conducted a systematic search of MEDLINE, Cochrane and Scopus, since their inceptions until January 2014, for articles evaluating SMF in the brachial artery and/or resistance arteries (BASMF and RASMF, respectively), as assessed by the endothelium-independent vasodilator response to exogenous nitric oxide donors in older (>= 60 years) and young (",

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T1 - The impact of age on vascular smooth muscle function in humans

AU - Montero, David

AU - Pierce, Gary L.

AU - Stehouwer, Coen D. A.

AU - Padilla, Jaume

AU - Thijssen, Dick H. J.

PY - 2015/3

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AB - Aim: Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exogenous nitric oxide donor, is typically reported to be intact, many of these studies are limited by a small sample size. Therefore, the purpose of this meta-analysis is to systematically review and determine whether vascular SMF is different between older versus young healthy individuals. Design: We conducted a systematic search of MEDLINE, Cochrane and Scopus, since their inceptions until January 2014, for articles evaluating SMF in the brachial artery and/or resistance arteries (BASMF and RASMF, respectively), as assessed by the endothelium-independent vasodilator response to exogenous nitric oxide donors in older (>= 60 years) and young (

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KW - conduit artery

KW - resistance arteries

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DO - 10.1097/HJH.0000000000000446

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