The impact of age on vascular smooth muscle function in humans

David Montero*, Gary L. Pierce, Coen D. A. Stehouwer, Jaume Padilla, Dick H. J. Thijssen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aim: Advanced age is associated with vascular endothelial dysfunction, characterized by reductions in the endothelium-dependent vasodilation of the conduit and resistance arteries, in part, from decreased nitric oxide bioavailability. Although vascular smooth muscle function (SMF), assessed by responsiveness to an exogenous nitric oxide donor, is typically reported to be intact, many of these studies are limited by a small sample size. Therefore, the purpose of this meta-analysis is to systematically review and determine whether vascular SMF is different between older versus young healthy individuals. Design: We conducted a systematic search of MEDLINE, Cochrane and Scopus, since their inceptions until January 2014, for articles evaluating SMF in the brachial artery and/or resistance arteries (BASMF and RASMF, respectively), as assessed by the endothelium-independent vasodilator response to exogenous nitric oxide donors in older (>= 60 years) and young (
Original languageEnglish
Pages (from-to)445-453
JournalJournal of Hypertension
Issue number3
Publication statusPublished - Mar 2015


  • advanced age
  • conduit artery
  • resistance arteries
  • vascular smooth muscle function

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