The IL-2-IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor

Jan Damoiseaux*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

43 Citations (Web of Science)

Abstract

The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Ra chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicting results on the function of sIL-2R are summarized. Finally, the added value of measuring sIL-2R in different types of diseases is being elaborated upon in terms of diagnosis, follow-up, and prognosis. Adequate interpretation of results is hampered by the apparent gap in our knowledge about the functional role of sIL-2R in immunity and tolerance.

Original languageEnglish
Article number108515
Number of pages9
JournalClinical Immunology
Volume218
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Interleukin 2
  • Interleukin 2 receptor
  • CD25
  • soluble IL-2R
  • Immunity
  • Tolerance
  • REGULATORY T-CELLS
  • INTERLEUKIN-2 RECEPTOR
  • RHEUMATOID-ARTHRITIS
  • MULTIPLE-SCLEROSIS
  • CYCLOSPORINE-A
  • HEMOPHAGOCYTIC SYNDROMES
  • ELEVATED LEVELS
  • SIL-2R LEVELS
  • SERUM-LEVELS

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