The IL-2-IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor

Jan Damoiseaux

doi:10.1016/j.clim.2020.108515

The IL-2-IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor

Jan Damoiseaux^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Ra chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicting results on the function of sIL-2R are summarized. Finally, the added value of measuring sIL-2R in different types of diseases is being elaborated upon in terms of diagnosis, follow-up, and prognosis. Adequate interpretation of results is hampered by the apparent gap in our knowledge about the functional role of sIL-2R in immunity and tolerance.

Original language	English
Article number	108515
Number of pages	9
Journal	Clinical Immunology
Volume	218
DOIs	https://doi.org/10.1016/j.clim.2020.108515
Publication status	Published - Sept 2020

Keywords

Interleukin 2
Interleukin 2 receptor
CD25
soluble IL-2R
Immunity
Tolerance
REGULATORY T-CELLS
INTERLEUKIN-2 RECEPTOR
RHEUMATOID-ARTHRITIS
MULTIPLE-SCLEROSIS
CYCLOSPORINE-A
HEMOPHAGOCYTIC SYNDROMES
ELEVATED LEVELS
SIL-2R LEVELS
SERUM-LEVELS

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Cite this

@article{088805ea879144deb447be38f58c9554,

title = "The IL-2-IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor",

abstract = "The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Ra chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicting results on the function of sIL-2R are summarized. Finally, the added value of measuring sIL-2R in different types of diseases is being elaborated upon in terms of diagnosis, follow-up, and prognosis. Adequate interpretation of results is hampered by the apparent gap in our knowledge about the functional role of sIL-2R in immunity and tolerance.",

keywords = "Interleukin 2, Interleukin 2 receptor, CD25, soluble IL-2R, Immunity, Tolerance, REGULATORY T-CELLS, INTERLEUKIN-2 RECEPTOR, RHEUMATOID-ARTHRITIS, MULTIPLE-SCLEROSIS, CYCLOSPORINE-A, HEMOPHAGOCYTIC SYNDROMES, ELEVATED LEVELS, SIL-2R LEVELS, SERUM-LEVELS",

author = "Jan Damoiseaux",

note = "Funding Information: Hereby I thank the students that participated in the course ?writing a systematic review? at Maastricht University in the years 2017 and 2018. With a focus on the paradoxes in the IL-2 ? IL-2R pathway, they paved the way for this review. I also thank Joyce van Beers for critical reading the manuscript. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: {\textcopyright} 2020 The Author",

year = "2020",

month = sep,

doi = "10.1016/j.clim.2020.108515",

language = "English",

volume = "218",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - The IL-2-IL-2 receptor pathway in health and disease

T2 - The role of the soluble IL-2 receptor

AU - Damoiseaux, Jan

N1 - Funding Information: Hereby I thank the students that participated in the course ?writing a systematic review? at Maastricht University in the years 2017 and 2018. With a focus on the paradoxes in the IL-2 ? IL-2R pathway, they paved the way for this review. I also thank Joyce van Beers for critical reading the manuscript. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2020 The Author

PY - 2020/9

Y1 - 2020/9

N2 - The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Ra chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicting results on the function of sIL-2R are summarized. Finally, the added value of measuring sIL-2R in different types of diseases is being elaborated upon in terms of diagnosis, follow-up, and prognosis. Adequate interpretation of results is hampered by the apparent gap in our knowledge about the functional role of sIL-2R in immunity and tolerance.

AB - The interleukin (IL)-2 - IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Ra chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce or enhance responses depending on the target cell being involved in immunity or self-tolerance. Since sIL-2R levels are increasingly measured in clinical practice, it is detrimental for clinical interpretation to understand the possible functional impact of IL-2R shedding. In this review the role of the IL-2 - IL-2R pathway is explored and the conflicting results on the function of sIL-2R are summarized. Finally, the added value of measuring sIL-2R in different types of diseases is being elaborated upon in terms of diagnosis, follow-up, and prognosis. Adequate interpretation of results is hampered by the apparent gap in our knowledge about the functional role of sIL-2R in immunity and tolerance.

KW - Interleukin 2

KW - Interleukin 2 receptor

KW - CD25

KW - soluble IL-2R

KW - Immunity

KW - Tolerance

KW - REGULATORY T-CELLS

KW - INTERLEUKIN-2 RECEPTOR

KW - RHEUMATOID-ARTHRITIS

KW - MULTIPLE-SCLEROSIS

KW - CYCLOSPORINE-A

KW - HEMOPHAGOCYTIC SYNDROMES

KW - ELEVATED LEVELS

KW - SIL-2R LEVELS

KW - SERUM-LEVELS

U2 - 10.1016/j.clim.2020.108515

DO - 10.1016/j.clim.2020.108515

M3 - (Systematic) Review article

C2 - 32619646

SN - 1521-6616

VL - 218

JO - Clinical Immunology

JF - Clinical Immunology

M1 - 108515

ER -