The hypoxic tumor microenvironment: from imaging to targeting

S.G.J.A. Peeters

doi:10.26481/dis.20150709sp

The hypoxic tumor microenvironment: from imaging to targeting

S.G.J.A. Peeters

GROW - Innovative Cancer Diagnostics & Therapy

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

A lack of oxygen caused by poorly formed blood vessels is a common phenomenon in tumours. These oxygen-poor (hypoxic) areas are less sensitive to existing anti-cancer therapies such as radiation therapy and chemotherapy. This dissertation has shown hypoxic areas in tumours by using PET imaging technology. The characteristics of three clinical hypoxia PET tracers were compared with each other in a preclinical tumour model. Next, the combination of a new drug specifically aimed at these hypoxic areas and radiation therapy was tested in a preclinical setting. The results being promising, a phase I study will be set up shortly to test this combined treatment on patients.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	Lambin, Philippe, Supervisor Dubois, Ludwig, Co-Supervisor
Award date	9 Jul 2015
Place of Publication	Maastricht
Publisher	Datawyse / Universitaire Pers Maastricht
Print ISBNs	9789461594501
DOIs	https://doi.org/10.26481/dis.20150709sp
Publication status	Published - 2015

Keywords

tumour
clinical hypoxia
PET scan

Access to Document

10.26481/dis.20150709sp

Full TextFinal published version, 1.71 MB
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Cite this

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