The Haemostatic System: Coagulation, Platelets, and Fibrinolysis

Coen Stehouwer, Marlien Peters, Moniek P.M. de Maat

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

The haemostatic or coagulant system is designed primarily to prevent bleeding and haemorrhage following injury to blood vessels, although some of its constituent proteins have additional roles in inflammation, angiogenesis, and tissue repair. This chapter describes the function and components of the haemostatic system and its role in the pathogenesis of cardiovascular disease (CVD). It explores the effect of variants in genes coding for proteins in the haemostatic system on cardiovascular risk. The chapter describes the effect of dietary components on the haemostatic system, both directly and via the development of chronic conditions, such as obesity and diabetes. Platelets have a key function in normal haemostasis and are activated by a number of agonists, particularly thrombin, collagen, adenosine diphosphate (ADP), and also adrenaline and serotonin, some of which act synergistically in vivo with other agonists. The fibrinolytic system regulates the degradation of the fibrin matrix. It consists of fibrinolytic factors and fibrinolysis inhibitors.
Original languageEnglish
Title of host publicationCardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, Second Edition
EditorsSara Stanner, Sarah Coe, Keith N. Frayn
PublisherWiley
Chapter8
Pages179-211
Number of pages33
ISBN (Electronic)9781118829875
ISBN (Print)9781118829912
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • adenosine diphosphate
  • cardiovascular disease
  • dietary components
  • fibrinolysis inhibitors
  • fibrinolytic system
  • genes coding
  • haemostatic system
  • obesity diabetes
  • platelets

Fingerprint

Dive into the research topics of 'The Haemostatic System: Coagulation, Platelets, and Fibrinolysis'. Together they form a unique fingerprint.

Cite this