The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

Lindsay Angus, Marcel Smid, Saskia M. Wilting, Job van Riet, Arne Van Hoeck, Luan Nguyen, Serena Nik-Zainal, Tessa G. Steenbruggen, Vivianne C. G. Tjan-Heijnen, Mariette Labots, Johanna M. G. H. van Riel, Haiko J. Bloemendal, Neeltje Steeghs, Martijn P. Lolkema, Emile E. Voest, Harmen J. G. van de Werken, Agnes Jager, Edwin Cuppen, Stefan Sleijfer, John W. M. Martens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1450-1458
Number of pages11
JournalNature Genetics
Volume51
Issue number10
DOIs
Publication statusPublished - Oct 2019

Keywords

  • EVOLUTION
  • VARIANTS
  • GERMLINE
  • PACKAGE
  • BRCA1

Cite this

Angus, L., Smid, M., Wilting, S. M., van Riet, J., Van Hoeck, A., Luan Nguyen, ... Martens, J. W. M. (2019). The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies. Nature Genetics, 51(10), 1450-1458. https://doi.org/10.1038/s41588-019-0507-7
Angus, Lindsay ; Smid, Marcel ; Wilting, Saskia M. ; van Riet, Job ; Van Hoeck, Arne ; Luan Nguyen ; Nik-Zainal, Serena ; Steenbruggen, Tessa G. ; Tjan-Heijnen, Vivianne C. G. ; Labots, Mariette ; van Riel, Johanna M. G. H. ; Bloemendal, Haiko J. ; Steeghs, Neeltje ; Lolkema, Martijn P. ; Voest, Emile E. ; van de Werken, Harmen J. G. ; Jager, Agnes ; Cuppen, Edwin ; Sleijfer, Stefan ; Martens, John W. M. / The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies. In: Nature Genetics. 2019 ; Vol. 51, No. 10. pp. 1450-1458.
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title = "The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies",
keywords = "EVOLUTION, VARIANTS, GERMLINE, PACKAGE, BRCA1",
author = "Lindsay Angus and Marcel Smid and Wilting, {Saskia M.} and {van Riet}, Job and {Van Hoeck}, Arne and {Luan Nguyen} and Serena Nik-Zainal and Steenbruggen, {Tessa G.} and Tjan-Heijnen, {Vivianne C. G.} and Mariette Labots and {van Riel}, {Johanna M. G. H.} and Bloemendal, {Haiko J.} and Neeltje Steeghs and Lolkema, {Martijn P.} and Voest, {Emile E.} and {van de Werken}, {Harmen J. G.} and Agnes Jager and Edwin Cuppen and Stefan Sleijfer and Martens, {John W. M.}",
year = "2019",
month = "10",
doi = "10.1038/s41588-019-0507-7",
language = "English",
volume = "51",
pages = "1450--1458",
journal = "Nature Genetics",
issn = "1061-4036",
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number = "10",

}

Angus, L, Smid, M, Wilting, SM, van Riet, J, Van Hoeck, A, Luan Nguyen, Nik-Zainal, S, Steenbruggen, TG, Tjan-Heijnen, VCG, Labots, M, van Riel, JMGH, Bloemendal, HJ, Steeghs, N, Lolkema, MP, Voest, EE, van de Werken, HJG, Jager, A, Cuppen, E, Sleijfer, S & Martens, JWM 2019, 'The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies', Nature Genetics, vol. 51, no. 10, pp. 1450-1458. https://doi.org/10.1038/s41588-019-0507-7

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies. / Angus, Lindsay; Smid, Marcel; Wilting, Saskia M.; van Riet, Job; Van Hoeck, Arne; Luan Nguyen; Nik-Zainal, Serena; Steenbruggen, Tessa G.; Tjan-Heijnen, Vivianne C. G.; Labots, Mariette; van Riel, Johanna M. G. H.; Bloemendal, Haiko J.; Steeghs, Neeltje; Lolkema, Martijn P.; Voest, Emile E.; van de Werken, Harmen J. G.; Jager, Agnes; Cuppen, Edwin; Sleijfer, Stefan; Martens, John W. M.

In: Nature Genetics, Vol. 51, No. 10, 10.2019, p. 1450-1458.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

AU - Angus, Lindsay

AU - Smid, Marcel

AU - Wilting, Saskia M.

AU - van Riet, Job

AU - Van Hoeck, Arne

AU - Luan Nguyen, null

AU - Nik-Zainal, Serena

AU - Steenbruggen, Tessa G.

AU - Tjan-Heijnen, Vivianne C. G.

AU - Labots, Mariette

AU - van Riel, Johanna M. G. H.

AU - Bloemendal, Haiko J.

AU - Steeghs, Neeltje

AU - Lolkema, Martijn P.

AU - Voest, Emile E.

AU - van de Werken, Harmen J. G.

AU - Jager, Agnes

AU - Cuppen, Edwin

AU - Sleijfer, Stefan

AU - Martens, John W. M.

PY - 2019/10

Y1 - 2019/10

KW - EVOLUTION

KW - VARIANTS

KW - GERMLINE

KW - PACKAGE

KW - BRCA1

U2 - 10.1038/s41588-019-0507-7

DO - 10.1038/s41588-019-0507-7

M3 - Article

VL - 51

SP - 1450

EP - 1458

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -