The future of brown adipose tissues in the treatment of type 2 diabetes

P. Schrauwen; W.D. van Marken Lichtenbelt; B.M. Spiegelman

doi:10.1007/s00125-015-3611-y

The future of brown adipose tissues in the treatment of type 2 diabetes

P. Schrauwen^*, W.D. van Marken Lichtenbelt, B.M. Spiegelman

^*Corresponding author for this work

Humane Biologie

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-called beige or brite adipocytes. So far, cold exposure is recognised as the strongest activator of BAT in humans, but there is much ongoing research focused on finding alternative activators of BAT. The consequences of long-term BAT activation and/or cold exposure on metabolic health are still unknown, and this represents an area of intensive research. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015).

Original language	English
Pages (from-to)	1704-1707
Number of pages	4
Journal	Diabetologia
Volume	58
Issue number	8
DOIs	https://doi.org/10.1007/s00125-015-3611-y
Publication status	Published - Aug 2015

Keywords

Brown adipose tissue
Cold-induced thermogenesis
Diabetes
Energy turnover
ENERGY-EXPENDITURE
COLD-EXPOSURE
ADULT HUMANS
ABLATION
MICE

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10.1007/s00125-015-3611-y

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Cite this

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title = "The future of brown adipose tissues in the treatment of type 2 diabetes",

abstract = "The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-called beige or brite adipocytes. So far, cold exposure is recognised as the strongest activator of BAT in humans, but there is much ongoing research focused on finding alternative activators of BAT. The consequences of long-term BAT activation and/or cold exposure on metabolic health are still unknown, and this represents an area of intensive research. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015).",

keywords = "Brown adipose tissue, Cold-induced thermogenesis, Diabetes, Energy turnover, ENERGY-EXPENDITURE, COLD-EXPOSURE, ADULT HUMANS, ABLATION, MICE",

author = "P. Schrauwen and {van Marken Lichtenbelt}, W.D. and B.M. Spiegelman",

year = "2015",

month = aug,

doi = "10.1007/s00125-015-3611-y",

language = "English",

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T1 - The future of brown adipose tissues in the treatment of type 2 diabetes

AU - Schrauwen, P.

AU - van Marken Lichtenbelt, W.D.

AU - Spiegelman, B.M.

PY - 2015/8

Y1 - 2015/8

N2 - The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-called beige or brite adipocytes. So far, cold exposure is recognised as the strongest activator of BAT in humans, but there is much ongoing research focused on finding alternative activators of BAT. The consequences of long-term BAT activation and/or cold exposure on metabolic health are still unknown, and this represents an area of intensive research. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015).

AB - The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-called beige or brite adipocytes. So far, cold exposure is recognised as the strongest activator of BAT in humans, but there is much ongoing research focused on finding alternative activators of BAT. The consequences of long-term BAT activation and/or cold exposure on metabolic health are still unknown, and this represents an area of intensive research. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015).

KW - Brown adipose tissue

KW - Cold-induced thermogenesis

KW - Diabetes

KW - Energy turnover

KW - ENERGY-EXPENDITURE

KW - COLD-EXPOSURE

KW - ADULT HUMANS

KW - ABLATION

KW - MICE

U2 - 10.1007/s00125-015-3611-y

DO - 10.1007/s00125-015-3611-y

M3 - Comment/Letter to the editor

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SN - 0012-186X

VL - 58

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JO - Diabetologia

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