The future of brown adipose tissues in the treatment of type 2 diabetes

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

14 Citations (Scopus)

Abstract

The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic disorders. Furthermore, it was also revealed that brown adipose tissue (BAT) in humans may consist of so-called beige or brite adipocytes. So far, cold exposure is recognised as the strongest activator of BAT in humans, but there is much ongoing research focused on finding alternative activators of BAT. The consequences of long-term BAT activation and/or cold exposure on metabolic health are still unknown, and this represents an area of intensive research. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015).
Original languageEnglish
Pages (from-to)1704-1707
Number of pages4
JournalDiabetologia
Volume58
Issue number8
DOIs
Publication statusPublished - Aug 2015

Keywords

  • Brown adipose tissue
  • Cold-induced thermogenesis
  • Diabetes
  • Energy turnover
  • ENERGY-EXPENDITURE
  • COLD-EXPOSURE
  • ADULT HUMANS
  • ABLATION
  • MICE

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