The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Isabelle Bos*, Stephanie J. Vos, Lutz Froelich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckhart Ruether, Sebastiaan Engelborghs, Ellis Niemantsverdriet, Ellen Elisa De Roeck, Magda Tsolaki, Yvonne Freund-Levim, Peter Johannsen, Rik Vandenberghe, Alberto Lleo, Daniel Alcolea, Giovanni B. Frisoni, Samantha Galluzzi, Flavio NobiliSilvia Morbelli, Alexander Drzezga, Mira Didic, Bart N. van Berckel, Eric Salmon, Christine Bastin, Solene Dauby, Isabel Santana, Ines Baldeiras, Alexandre de Mendonca, Dina Silva, Anders Wallin, Arto Nordlund, Preciosa M. Coloma, Angelika Wientzek, Myriam Alexander, Gerald P. Novak, Mark Forrest Gordon, Asa K. Wallin, Harald Hampel, Hilkka Soininen, Sanna-Kaisa Herukka, Philip Scheltens, Frans R. Verhey, Pieter Jelle Visser, Alzheimer's Disease Neuroimaging Initiative

*Corresponding author for this work

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Abstract

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Coxregression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hyper-cholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD. (C) 2017 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalNeurobiology of Aging
Volume56
DOIs
Publication statusPublished - Aug 2017

Keywords

  • Alzheimer's disease
  • Risk factors
  • IWG-2 criteria
  • NIA-AA criteria
  • Biomarkers
  • Prognosis
  • MILD COGNITIVE IMPAIRMENT
  • CEREBROSPINAL-FLUID BIOMARKERS
  • VASCULAR RISK
  • ALCOHOL-CONSUMPTION
  • DECLINE
  • ASSOCIATION
  • DIAGNOSIS
  • METAANALYSIS
  • PREVALENCE
  • GUIDELINES

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