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The evolutionary benefit of insulin resistance
M.R. Soeters
*
, P.B. Soeters
*
*
Corresponding author for this work
Surgery
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peer-review
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Keyphrases
Insulin Resistance
100%
Evolutionary Implications
100%
Tricarboxylic Acid Cycle (TCA cycle)
14%
Type 2 Diabetes Mellitus (T2DM)
14%
Metabolic Syndrome
14%
Immune Activation
14%
Cellular Tissue
14%
Insulin Sensitivity
14%
Energy Demand
14%
Fatty Acids
14%
Beneficial Role
14%
Whole Organism
14%
Critical Illness
14%
Anaplerosis
14%
Glucose Oxidation
14%
Starvation
14%
Low Demand
14%
Oxaloacetate
14%
Pentose Phosphate Pathway
14%
Cellular Organisms
14%
Ketone Body Oxidation
14%
Syndrome Type
14%
Metabolic Pathways
14%
Nicotinamide Adenine Dinucleotide Phosphate (NADPH)
14%
INIS
insulin
100%
glucose
25%
oxidation
25%
levels
12%
phosphates
12%
cancer
12%
sensitivity
12%
tissues
12%
diabetes mellitus
12%
fatty acids
12%
nucleotides
12%
production
12%
growth
12%
energy demand
12%
ketones
12%
starvation
12%
metabolic pathways
12%
pentoses
12%
Pharmacology, Toxicology and Pharmaceutical Science
Insulin Resistance
100%
Glucose
28%
Fatty Acid
14%
Malignant Neoplasm
14%
Metabolic Syndrome X
14%
Tricarboxylic Acid
14%
Ketone Bodies
14%
Critical Illness
14%
Pentose Phosphate
14%
Reduced Nicotinamide Adenine Dinucleotide Phosphate
14%
Oxaloacetic Acid
14%
Insulin
14%
Maturity Onset Diabetes of the Young
14%
Biochemistry, Genetics and Molecular Biology
Insulin Resistance
100%
Insulin Sensitivity
14%
Citric Acid Cycle
14%
Anaplerosis
14%
Glucose Oxidation
14%
Ketone Bodies
14%
Hexose Monophosphate Shunt
14%
Maturity Onset Diabetes of the Young
14%
Glucose
14%
Nucleotide
14%
Fatty Acid
14%
Chemistry
Tricarboxylic Acid
12%
Growth Activation
12%
Agricultural and Biological Sciences
Nucleotide
14%