The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation

Laurien De Roeck; Hiska L van der Weide; Daniëlle B P Eekers; Miranda C Kramer; Claire Alapetite; Malin Blomstrand; Neil G Burnet; Valentin Calugaru; Ida E M Coremans; Dario Di Perri; Semi Harrabi; Alberto Iannalfi; Yvonne L B Klaver; Johannes A Langendijk; Alejandra Méndez Romero; Frank Paulsen; Erik Roelofs; Dirk de Ruysscher; Beate Timmermann; Pavel Vitek; Damien C Weber; Gillian A Whitfield; Petra Witt Nyström; Jaap Zindler; Esther G C Troost; Maarten Lambrecht; work package 1 of the taskforce “European Particle Therapy Network” of ESTRO

doi:10.1016/j.radonc.2022.01.018

The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation

Laurien De Roeck^*, Hiska L van der Weide, Daniëlle B P Eekers, Miranda C Kramer, Claire Alapetite, Malin Blomstrand, Neil G Burnet, Valentin Calugaru, Ida E M Coremans, Dario Di Perri, Semi Harrabi, Alberto Iannalfi, Yvonne L B Klaver, Johannes A Langendijk, Alejandra Méndez Romero, Frank Paulsen, Erik Roelofs, Dirk de Ruysscher, Beate Timmermann, Pavel VitekDamien C Weber, Gillian A Whitfield, Petra Witt Nyström, Jaap Zindler, Esther G C Troost, Maarten Lambrecht, work package 1 of the taskforce “European Particle Therapy Network” of ESTRO

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy.

METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points.

RESULTS: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined.

CONCLUSION: These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.

Original language	English
Pages (from-to)	241-249
Number of pages	9
Journal	Radiotherapy and Oncology
Volume	168
Early online date	29 Jan 2022
DOIs	https://doi.org/10.1016/j.radonc.2022.01.018
Publication status	Published - Mar 2022

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10.1016/j.radonc.2022.01.018

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De Roeck, L., van der Weide, H. L., Eekers, D. B. P., Kramer, M. C., Alapetite, C., Blomstrand, M., Burnet, N. G., Calugaru, V., Coremans, I. E. M., Di Perri, D., Harrabi, S., Iannalfi, A., Klaver, Y. L. B., Langendijk, J. A., Romero, A. M., Paulsen, F., Roelofs, E., de Ruysscher, D., Timmermann, B., ... work package 1 of the taskforce “European Particle Therapy Network” of ESTRO (2022). The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation. Radiotherapy and Oncology, 168, 241-249. https://doi.org/10.1016/j.radonc.2022.01.018

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title = "The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation",

abstract = "PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy.METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points.RESULTS: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined.CONCLUSION: These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.",

author = "{De Roeck}, Laurien and {van der Weide}, {Hiska L} and Eekers, {Dani{\"e}lle B P} and Kramer, {Miranda C} and Claire Alapetite and Malin Blomstrand and Burnet, {Neil G} and Valentin Calugaru and Coremans, {Ida E M} and {Di Perri}, Dario and Semi Harrabi and Alberto Iannalfi and Klaver, {Yvonne L B} and Langendijk, {Johannes A} and Romero, {Alejandra M{\'e}ndez} and Frank Paulsen and Erik Roelofs and {de Ruysscher}, Dirk and Beate Timmermann and Pavel Vitek and Weber, {Damien C} and Whitfield, {Gillian A} and Nystr{\"o}m, {Petra Witt} and Jaap Zindler and Troost, {Esther G C} and Maarten Lambrecht and {work package 1 of the taskforce “European Particle Therapy Network” of ESTRO}",

year = "2022",

month = mar,

doi = "10.1016/j.radonc.2022.01.018",

language = "English",

volume = "168",

pages = "241--249",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

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De Roeck, L, van der Weide, HL, Eekers, DBP, Kramer, MC, Alapetite, C, Blomstrand, M, Burnet, NG, Calugaru, V, Coremans, IEM, Di Perri, D, Harrabi, S, Iannalfi, A, Klaver, YLB, Langendijk, JA, Romero, AM, Paulsen, F, Roelofs, E , de Ruysscher, D, Timmermann, B, Vitek, P, Weber, DC, Whitfield, GA, Nyström, PW, Zindler, J, Troost, EGC, Lambrecht, M & work package 1 of the taskforce “European Particle Therapy Network” of ESTRO 2022, 'The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation', Radiotherapy and Oncology, vol. 168, pp. 241-249. https://doi.org/10.1016/j.radonc.2022.01.018

The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation. / De Roeck, Laurien; van der Weide, Hiska L; Eekers, Daniëlle B P et al.
In: Radiotherapy and Oncology, Vol. 168, 03.2022, p. 241-249.

Research output: Contribution to journal › (Systematic) Review article › peer-review

TY - JOUR

T1 - The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation

AU - De Roeck, Laurien

AU - van der Weide, Hiska L

AU - Eekers, Daniëlle B P

AU - Kramer, Miranda C

AU - Alapetite, Claire

AU - Blomstrand, Malin

AU - Burnet, Neil G

AU - Calugaru, Valentin

AU - Coremans, Ida E M

AU - Di Perri, Dario

AU - Harrabi, Semi

AU - Iannalfi, Alberto

AU - Klaver, Yvonne L B

AU - Langendijk, Johannes A

AU - Romero, Alejandra Méndez

AU - Paulsen, Frank

AU - Roelofs, Erik

AU - de Ruysscher, Dirk

AU - Timmermann, Beate

AU - Vitek, Pavel

AU - Weber, Damien C

AU - Whitfield, Gillian A

AU - Nyström, Petra Witt

AU - Zindler, Jaap

AU - Troost, Esther G C

AU - Lambrecht, Maarten

AU - work package 1 of the taskforce “European Particle Therapy Network” of ESTRO

PY - 2022/3

Y1 - 2022/3

N2 - PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy.METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points.RESULTS: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined.CONCLUSION: These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.

AB - PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy.METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points.RESULTS: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined.CONCLUSION: These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.

U2 - 10.1016/j.radonc.2022.01.018

DO - 10.1016/j.radonc.2022.01.018

M3 - (Systematic) Review article

C2 - 35093408

SN - 0167-8140

VL - 168

SP - 241

EP - 249

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -