The European Eye Epidemiology spectral-domain optical coherence tomography classification of macular diseases for epidemiological studies

Sarra Gattoussi, Gabrielle H. S. Buitendijk, Tunde Peto, Irene Leung, Steffen Schmitz-Valckenberg, Akio Oishi, Sebastian Wolf, Gabor Deak, Ccile Delcourt*, Caroline C. W. Klaver, Jean-Fracnois Korobelnik, Niyazi Acar, Eleftherios Anas-Tosopoulos, Augusto Azuara-Blanco, Tos Berendschot, Geir Bertelsen, Christine Binquet, Alan Bird, Martin Bobak, Morten Bogelund LarsenCamiel Boon, Rupert Bourne, Lionel Bretillon, Rebecca Broe, Alain Bron, Gabrielle Buitendijk, Maria Luz Cachulo, Vittorio Capuano, Isabelle Carriere, Usha Chakravarthy, Michelle Chan, Petrus Chang, Johanna Colijn, Angela Cree, Catherine Creuzot-Garcher, Phillippa Cumberland, Jose Cunha-Vaz, Vincent Daien, Eiko De Jong, Gabor Deak, Cecile Delcourt, Marie-Noelle Delyfer, Anneke den Hollan-Der, Martha Dietzel, Maja Gran Erke, Pedro Faria, Claudia Farinha, Sascha Fauser, Robert Finger, Theo Gorgels, European Eye Epidemiology (E3) Consortium

*Corresponding author for this work

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Abstract

Purpose The aim of the European Eye Epidemiology (E3) consortium was to develop a spectral-domain optical coherence tomography (SD-OCT)-based classification for macular diseases to standardize epidemiological studies. Methods A European panel of vitreoretinal disease experts and epidemiologists belonging to the E3 consortium was assembled to define a classification for SD-OCT imaging of the macula. A series of meeting was organized, to develop, test and finalize the classification. First, grading methods used by the different research groups were presented and discussed, and a first version of classification was proposed. This first version was then tested on a set of 50 SD-OCT images in the Bordeaux and Rotterdam centres. Agreements were analysed and discussed with the panel of experts and a final version of the classification was produced. Results Definitions and classifications are proposed for the structure assessment of the vitreomacular interface (visibility of vitreous interface, vitreomacular adhesion, vitreomacular traction, epiretinal membrane, full-thickness macular hole, lamellar macular hole, macular pseudo-hole) and of the retina (retinoschisis, drusen, pigment epithelium detachment, hyper-reflective clumps, retinal pigment epithelium atrophy, intraretinal cystoid spaces, intraretinal tubular changes, subretinal fluid, subretinal material). Classifications according to size and location are defined. Illustrations of each item are provided, as well as the grading form. Conclusion The E3 SD-OCT classification has been developed to harmonize epidemiological studies. This homogenization will allow comparing and sharing data collection between European and international studies.

Original languageEnglish
Pages (from-to)364-371
Number of pages8
JournalActa Ophthalmologica
Volume97
Issue number4
DOIs
Publication statusPublished - Jun 2019

Keywords

  • epidemiology
  • macular degeneration
  • optical coherence tomography
  • retina
  • vitreous
  • NERVE-FIBER LAYER
  • AGE-RELATED MACULOPATHY
  • VITREOMACULAR TRACTION
  • SD-OCT
  • THICKNESS
  • POPULATION
  • PREVALENCE
  • SEGMENTATION
  • DEGENERATION
  • ABNORMALITIES

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