The estimation of a preference-based single index for the IBS-QoL by mapping to the EQ-5D-5L in patients with irritable bowel syndrome

R. Sturkenboom*, D. Keszthelyi, L. Brandts, Z.Z.R.M. Weerts, J.T.W. Snijkers, A.A.M. Masclee, B.A.B. Essers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Purpose The Irritable Bowel Syndrome Quality of Life (IBS-QoL) questionnaire is a commonly used and validated IBS-specific QoL instrument. However, this questionnaire is in contrast to the EQ-5D-5L, not preference-based and as such does not allow calculation of QALYs. The objective of this study was to describe the convergent- and known-group validity of both questionnaires and to develop a mapping algorithm from EQ-5D-5L which enable IBS-QoL scores to be transformed into utility scores for use in economic evaluations. Methods We used data from two multicenter randomized clinical trials, which represented the estimation and external validation dataset. The convergent validity was investigated by examining correlations between the EQ-5D-5L and IBS-QoL and the known-group validity by calculating effect sizes. Ordinary least squares (OLS), censored least absolute deviations (CLAD), and mixture models were used in this mapping approach. Results 283 IBS patients were included (n = 189 vs. n = 84). Mean IBS-QoL score was 71.13 (SD 15.66) and mean EQ-5D-5L utility score was 0.73 (SD 0.19). The overall sensitivity of the IBS-QoL and EQ-5D-5L to discriminate between patient and disease characteristics was similar. CLAD model 4, containing the total IBS-QoL score and squared IBS-SSS (IBS severity scoring system), was chosen as the most appropriate model to transform IBS-QoL scores into EQ-5D-5L utility scores. Conclusion This study reports the development of an algorithm where the condition-specific questionnaire IBS-QoL can be used to calculate utility values for use in economic evaluations. Including a clinical measure, IBS-SSS, in the model improved the performance of the algorithm.
Original languageEnglish
Pages (from-to)1209-1221
Number of pages13
JournalQuality of Life Research
Volume31
Issue number4
Early online date21 Sep 2021
DOIs
Publication statusPublished - Apr 2022

Keywords

  • Mapping
  • EQ-5D-5L
  • IBS-QoL
  • Irritable bowel syndrome
  • Utility
  • Quality of life
  • QUALITY-OF-LIFE
  • HEALTH-STATE UTILITY
  • DISEASE-SPECIFIC MEASURES
  • VARIABLE MIXTURE-MODELS
  • WORK PRODUCTIVITY
  • VALIDATION
  • QUESTIONNAIRE
  • DEPRESSION
  • REGRESSION
  • SEVERITY

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